CYSLTR1 - Cysteinyl leukotriene receptor 1 - human protein (Function)
 
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CYSLTR1 »  Cysteinyl leukotriene receptor 1  (CysLTR1)
 
Protein also known as:  Cysteinyl leukotriene D4 receptor (LTD4 receptor).
Gene name:  CYSLTR1
Entry whose protein(s) existence is based on evidence at protein level
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1 56 1
GENE REF ISO

Function

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Overview 
Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the g-protein-coupled receptor (gpcr) family  9.A.14.13.2  
GO molecular function 
Leukotriene receptor activitydefinition[GO:0004974] silver  
  • IEAOrtholog Compara
GO biological process 
Calcium ion transportdefinition[GO:0006816] silver  
  • IEAOrtholog Compara
Chemotaxisdefinition[GO:0006935] silver  
  • IEAOrtholog Compara
Defense responsedefinition[GO:0006952]  
1
  • TASPINC
Inflammatory responsedefinition[GO:0006954] silver  
  • IEAOrtholog Compara
Positive regulation of angiogenesisdefinition[GO:0045766] silver  
  • IEAOrtholog Compara
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204]  
1
  • TASPINC
Positive regulation of vasoconstrictiondefinition[GO:0045907] silver  
  • IEAOrtholog Compara
Respiratory gaseous exchangedefinition[GO:0007585]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+10800  
Neuroactive ligand-receptor interaction  hsa04080+10800  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
Note 
Selective antagonists, such as montelukast (Singulair), zafirlukast (Accolate) and pranlukast (Onon), are used in the treatment of the asthma crisis.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Cysteinyl_leukotriene_receptor_1
GenomeRNAi: 10800
PRO: PR:Q9Y271
Chemistry
GuidetoPHARMACOLOGY: 269