INVS - Inversin - human protein (Function)
 
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Protein
Gene
References

 
INVS »  Inversin
 
Protein also known as:  Inversion of embryo turning homolog.
Gene name:  INVS
Entry whose protein(s) existence is based on evidence at protein level
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1 40 3
GENE REF ISO

Function

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Overview 
Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity).  
2
  • CuratedUniProtKB
GO molecular function 
Calmodulin bindingdefinition[GO:0005516]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
  • IPIUniProtKB
GO biological process 
Embryonic heart tube left/right pattern formationdefinition[GO:0060971] silver  
  • IEAOrtholog Compara
Kidney developmentdefinition[GO:0001822] silver  
  • IEAOrtholog Compara
Negative regulation of canonical Wnt signaling pathwaydefinition[GO:0090090]  
1
  • IDAUniProtKB
Pancreas developmentdefinition[GO:0031016] silver  
  • IEAOrtholog Compara
Post-embryonic developmentdefinition[GO:0009791] silver  
  • IEAOrtholog Compara
Wnt signaling pathwaydefinition[GO:0016055]  
  • IEAUniProtKB KW
 

Keywords

Biological process 
Wnt signaling pathway  definition   [KW-0879]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: INVS
GenomeRNAi: 27130
PRO: PR:Q9Y283