ITM2B - Integral membrane protein 2B - human protein (Function)
 
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ITM2B »  Integral membrane protein 2B
 
Protein also known as:  Transmembrane protein BRI (Bri). Cleaved into:  BRI2 intracellular domain; BRI2, membrane form; BRI2C, soluble form; Bri23 peptide.
Gene name:  ITM2B
Family name: ITM2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 42 1
GENE REF ISO

Function

 show evidences
Overview 
Plays a regulatory role in the processing of the beta-amyloid A4 precursor protein (APP) and acts as an inhibitor of the beta-amyloid peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites.  
8
  • CuratedUniProtKB
Mature BRI2 (mBRI2) functions as a modulator of the beta-amyloid A4 precursor protein (APP) processing leading to a strong reduction in the secretion of secretase-processed beta-amyloid protein 40 and beta-amyloid protein 42.  
8
  • CuratedUniProtKB
Bri23 peptide prevents aggregation of APP beta-amyloid protein 42 peptide into toxic oligomers.  
8
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524] silver  
  • IEAOrtholog Compara
Beta-amyloid bindingdefinition[GO:0001540]  
1
  • IPIBHF-UCL
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
GO biological process 
Extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:0097192] silver  
  • IEAOrtholog Compara
Negative regulation of amyloid precursor protein biosynthetic processdefinition[GO:0042985]  
2
  • IDAUniProtKB
Nervous system developmentdefinition[GO:0007399]  
1
  • TASPINC
Pathways 
According to Reactome, this protein belongs to the following pathway:
Disease  REACT_116125  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ITM2B
GenomeRNAi: 9445
PRO: PR:Q9Y287