B3GNT3 - N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3 - human protein (Function)
 
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B3GNT3 »  N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3   [ EC 2.4.1.149 ]
 
Protein also known as:  Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase [EC 2.4.1.146].
Gene name:  B3GNT3
Family name: Glycosyltransferase 31
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Has activity for type 2 oligosaccharides (PubMed11042166). Also acts as a core1-1,3-N-acetylglucosaminyltransferase (Core1-beta3GlcNAcT) to form the 6-sulfo sialyl Lewis x on extended core1 O-glycans (PubMed11439191).  
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  • UniProtKB
GO molecular function 
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activitydefinition[GO:0047223]  
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  • EC 2 GO
Galactosyltransferase activitydefinition[GO:0008378] silver  
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  • InterPro 2 GO
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activitydefinition[GO:0008532]  
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  • UniProtKB
GO biological process 
Poly-N-acetyllactosamine biosynthetic processdefinition[GO:0030311]  
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  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 2.4.1.146: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->3)-(N-acetyl-D-glucosaminyl-(1->6))-N-acetyl-D-galactosaminyl-R UDP + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-(N-acetyl-D-glucosaminyl-(1->6))-N-acetyl-D-galactosaminyl-R.  
2
  • UniProtKB
EC 2.4.1.149: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R UDP + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R.  
2
  • UniProtKB
According to CAZy, this protein is belongs to the following pathway:
Glycosyltransferase Family 31  GT31  
 
More information is available from:
Pathways 
This protein is involved in the following pathway
Protein modification; protein glycosylation  
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  • UniProtKB
According to KEGG, this protein belongs to the following pathways:
Glycosphingolipid biosynthesis - lacto and neolacto series  hsa00601+10331  
Metabolic pathways  hsa01100+10331  
According to Reactome, this protein belongs to the following pathways:
Keratan sulfate biosynthesis  REACT_121120  
O-linked glycosylation of mucins  REACT_115606  
 
More information is available from:
 

Keywords

Molecular function 
Glycosyltransferase  definition   [KW-0328]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links