SLC9A8 - Sodium/hydrogen exchanger 8 - human protein (Function)
 
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Protein
Gene
References

 
SLC9A8 »  Sodium/hydrogen exchanger 8
 
Protein also known as:  Solute carrier family 9 member 8.
Gene name:  SLC9A8
Entry whose protein(s) existence is based on evidence at protein level
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1 24 2
GENE REF ISO

Function

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Overview 
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the monovalent cation:proton antiporter-1 (cpa1) family  2.A.36.1.9  
GO molecular function 
Potassium:hydrogen antiporter activitydefinition[GO:0015386] silver  
  • IEAOrtholog Compara
Sodium:hydrogen antiporter activitydefinition[GO:0015385] silver  
  • IEAOrtholog Compara
GO biological process 
Regulation of intracellular pHdefinition[GO:0051453] silver  
  • IEAOrtholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathway:
Transmembrane transport of small molecules  REACT_15518  
 

Keywords

Biological process 
Antiport  definition   [KW-0050]
Ion transport  definition   [KW-0406]
Sodium transport  definition   [KW-0739]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SLC9A8
GenomeRNAi: 23315
PRO: PR:Q9Y2E8