MYRF - Myelin regulatory factor - human protein (Function)
 
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MYRF »  Myelin regulatory factor   [ EC 3.4.-.- ]
 
Protein also known as:  Myelin gene regulatory factor. Cleaved into:  Myelin regulatory factor, C-terminal; Myelin regulatory factor, N-terminal.
Gene name:  MYRF
Family name: MRF
Entry whose protein(s) existence is based on evidence at protein level
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1 18 2
GENE REF ISO

Function

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Overview 
Myelin regulatory factor: Consitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes (PubMed23966832).  
1
  • CuratedUniProtKB
Myelin regulatory factor, C-terminal: Membrane-bound part that has no transcription factor activity and remains attached to the endoplasmic reticulum membrane following cleavage (PubMed23966832).  
1
  • CuratedUniProtKB
Myelin regulatory factor, N-terminal: Transcription factor that specifically activates expression of myelin genes such as MBP, MOG, MAG and PLP1 during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Specifically recognizes and binds DNA sequence 5'-CTGGYAC-3' in the regulatory regions of myelin-specific genes and directly activates their expression. Not only required during oligodendrocyte differentiation but is also required on an ongoing basis for the maintenance of expression of myelin genes and for the maintenance of a mature, viable oligodendrocyte phenotype (PubMed23966832).  
1
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
  • IEAUniProtKB KW
Peptidase activitydefinition[GO:0008233]  
  • IEAUniProtKB KW
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAInterPro 2 GO
GO biological process 
Central nervous system myelin maintenancedefinition[GO:0032286]  
  • ISSOrtholog Curator
Central nervous system myelinationdefinition[GO:0022010]  
  • ISSOrtholog Curator
Oligodendrocyte developmentdefinition[GO:0014003]  
  • ISSOrtholog Curator
Oligodendrocyte differentiationdefinition[GO:0048709]  
  • ISSOrtholog Curator
Positive regulation of myelinationdefinition[GO:0031643]  
  • ISSOrtholog Curator
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
  • ISSOrtholog Curator
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Myelin_gene_Regulatory_Factor
GenomeRNAi: 745