MRF - Myelin gene regulatory factor - human protein (Function)
 
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Protein
Gene
References

 
MRF »  Myelin gene regulatory factor
 
Gene name:  MRF
Family name: MRF
One or more isoforms of this protein have been shown to exist at protein level
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1 8 2
GENE REF ISO

Function

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Overview 
Transcription regulator required for expression of CNS myelin genes such as Mbp, Mog, Mag and Plp1 thereby playing a central role in oligodendrocyte maturation and central nervous system (CNS) myelination. It is not only required during oligodendrocyte differentiation but is also required on an ongoing basis for the maintenance of expression of myelin genes and for the maintenance of a mature, viable oligodendrocyte phenotype (By similarity).  
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
  • IEAUniProtKB KW
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAInterPro 2 GO
GO biological process 
Central nervous system myelin maintenancedefinition[GO:0032286]  
  • ISSOrtholog Curator
Central nervous system myelinationdefinition[GO:0022010]  
  • ISSOrtholog Curator
Oligodendrocyte developmentdefinition[GO:0014003]  
  • ISSOrtholog Curator
Oligodendrocyte differentiationdefinition[GO:0048709]  
  • ISSOrtholog Curator
Positive regulation of myelinationdefinition[GO:0031643]  
  • ISSOrtholog Curator
Positive regulation of transcription, DNA-dependentdefinition[GO:0045893]  
  • ISSOrtholog Curator
Transcription, DNA-dependentdefinition[GO:0006351]  
  • IEAUniProtKB KW
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]