ATP11B - Probable phospholipid-transporting ATPase IF - human protein (Function)
 
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ATP11B »  Probable phospholipid-transporting ATPase IF
 
Gene name:  ATP11B
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). Involved in regulation of sensitivity to cisplatin; may contribute to secretory vesicle transport of cisplatin from Golgi to plasma membrane.  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the p-type atpase (p-atpase) superfamily  3.A.3.8.12  
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Cation-transporting ATPase activitydefinition[GO:0019829] silver  
  • IEAInterPro 2 GO
Ion transmembrane transporter activitydefinition[GO:0015075]  
1
  • NASUniProtKB
Magnesium ion bindingdefinition[GO:0000287] silver  
  • IEAInterPro 2 GO
Phospholipid-translocating ATPase activitydefinition[GO:0004012]  
1
  • TASUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
GO biological process 
Aminophospholipid transportdefinition[GO:0015917]  
1
  • TASUniProtKB
Cation transportdefinition[GO:0006812] silver  
  • IEAInterPro 2 GO
Ion transportdefinition[GO:0006811]  
1
  • NASUniProtKB
Metabolic processdefinition[GO:0008152]  
  • IEAUniProtKB KW
Phospholipid translocationdefinition[GO:0045332]  
1
  • NASUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.3.1: ATP + H(2)O + phospholipid(Side 1) ADP + phosphate + phospholipid(Side 2).  
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Ion transport by P-type ATPases  REACT_25149  
Note 
Depletion of ATP11B by RNAi restores sensitivity of ovarian cancer cells to cisplatin.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Lipid transport  definition   [KW-0445]
Transport  definition   [KW-0813]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ATP11B
GenomeRNAi: 23200
PRO: PR:Q9Y2G3