PTPN22 - Tyrosine-protein phosphatase non-receptor type 22 - human protein (Function)
 
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PTPN22 »  Tyrosine-protein phosphatase non-receptor type 22   [ EC 3.1.3.48 ]
 
Protein also known as:  Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP.
Gene name:  PTPN22
Entry whose protein(s) existence is based on evidence at protein level
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1 243 6
GENE REF ISO

Function

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Overview 
Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PubMed16461343, PubMed18056643). Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue (PubMed21719704). Dephosphorylates ZAP70 at its activating 'Tyr-493' residue (PubMed16461343). Dephosphorylates the immune system activator SKAP2 (PubMed21719704). Positively regulates toll-like receptor (TLR)-induced type 1 interferon production (PubMed23871208). Promotes host antiviral responses mediated by type 1 interferon (By similarity). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy (PubMed23991106).  
8
  • UniProtKB
GO molecular function 
Kinase bindingdefinition[GO:0019900]  
1
  • Ortholog Curator
Phosphatase activitydefinition[GO:0016791]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
7
  • IntAct
  • BHF-UCL
Protein tyrosine phosphatase activitydefinition[GO:0004725]  
3
  • UniProtKB
  • BHF-UCL
SH3 domain bindingdefinition[GO:0017124]  
1
  • Ortholog Curator
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
1
  • UniProtKB
GO biological process 
Autophagydefinition[GO:0006914]  
1
  • UniProtKB KW
Lipopolysaccharide-mediated signaling pathwaydefinition[GO:0031663]  
1
  • UniProtKB
Negative regulation of autophagydefinition[GO:0010507]  
1
  • UniProtKB
Negative regulation of gene expressiondefinition[GO:0010629]  
1
  • UniProtKB
Negative regulation of interleukin-6 secretiondefinition[GO:1900165]  
1
  • UniProtKB
Negative regulation of interleukin-8 secretiondefinition[GO:2000483]  
1
  • UniProtKB
Negative regulation of JUN kinase activitydefinition[GO:0043508]  
1
  • UniProtKB
Negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathwaydefinition[GO:0070433]  
1
  • UniProtKB
Negative regulation of p38MAPK cascadedefinition[GO:1903753]  
1
  • UniProtKB
Negative regulation of T cell activationdefinition[GO:0050868]  
1
  • BHF-UCL
Negative regulation of T cell receptor signaling pathwaydefinition[GO:0050860]  
1
  • UniProtKB
Negative regulation of tumor necrosis factor productiondefinition[GO:0032720]  
1
  • UniProtKB
Peptidyl-tyrosine dephosphorylationdefinition[GO:0035335]  
5
  • GOC
  • InterPro 2 GO
  • EC 2 GO
Phosphoanandamide dephosphorylationdefinition[GO:0035644]  
1
  • Ortholog Curator
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374]  
1
  • UniProtKB
Positive regulation of gene expressiondefinition[GO:0010628]  
1
  • UniProtKB
Positive regulation of interferon-gamma secretiondefinition[GO:1902715]  
1
  • UniProtKB
Positive regulation of protein K63-linked ubiquitinationdefinition[GO:1902523]  
1
  • UniProtKB
Positive regulation of toll-like receptor 3 signaling pathwaydefinition[GO:0034141]  
1
  • UniProtKB
Positive regulation of toll-like receptor 4 signaling pathwaydefinition[GO:0034145]  
1
  • UniProtKB
Positive regulation of type I interferon productiondefinition[GO:0032481]  
1
  • UniProtKB
Protein dephosphorylationdefinition[GO:0006470]  
2
  • BHF-UCL
Regulation of B cell receptor signaling pathwaydefinition[GO:0050855]  
1
  • BHF-UCL
Regulation of innate immune responsedefinition[GO:0045088]  
1
  • BHF-UCL
Regulation of natural killer cell proliferationdefinition[GO:0032817]  
1
  • BHF-UCL
Regulation of NIK/NF-kappaB signalingdefinition[GO:1901222]  
1
  • UniProtKB
T cell differentiationdefinition[GO:0030217]  
1
  • Ortholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.3.48: Protein tyrosine phosphate + H(2)O protein tyrosine + phosphate.  
3
  • UniProtKB
  • PROSITE-ProRule
It is regulated in the following manner
Down-regulated by phosphorylation.  
1
  • UniProtKB
 
More information is available from:
 

Keywords

Biological process 
Autophagy  definition   [KW-0072]
Immunity  definition   [KW-0391]
Molecular function 
Hydrolase  definition   [KW-0378]
Protein phosphatase  definition   [KW-0904]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PTPN22
GenomeRNAi: 26191
PRO: PR:Q9Y2R2