POLR1D - DNA-directed RNA polymerases I and III subunit RPAC2 - human protein (Function)
 
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POLR1D »  DNA-directed RNA polymerases I and III subunit RPAC2  (RNA polymerases I and III subunit AC2)
 
Protein also known as:  DNA-directed RNA polymerase I subunit D.
Gene name:  POLR1D
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 21 2
GENE REF ISO

Function

 show evidences
Overview 
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively.  
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677] silver  
  • IEAInterPro 2 GO
Protein dimerization activitydefinition[GO:0046983] silver  
  • IEAInterPro 2 GO
Contributes to RNA polymerase I activitydefinition[GO:0001054] silver  
  • IBARefGenome
Contributes to RNA polymerase III activitydefinition[GO:0001056] silver  
  • IBARefGenome
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cytosolic DNA-sensing pathway  hsa04623+51082  
Metabolic pathways  hsa01100+51082  
Purine metabolism  hsa00230+51082  
Pyrimidine metabolism  hsa00240+51082  
RNA polymerase  hsa03020+51082  
According to Reactome, this protein belongs to the following pathways:
NoRC negatively regulates rRNA expression  REACT_200856  
RNA Polymerase I Chain Elongation  REACT_2204  
RNA Polymerase I Promoter Escape  REACT_1913  
RNA Polymerase I Transcription Initiation  REACT_953  
RNA Polymerase I Transcription Termination  REACT_1074  
RNA Polymerase III Abortive And Retractive Initiation  REACT_22339  
RNA Polymerase III Chain Elongation  REACT_756  
RNA Polymerase III Transcription Initiation From Type 1 Promoter  REACT_347  
RNA Polymerase III Transcription Initiation From Type 2 Promoter  REACT_1036  
RNA Polymerase III Transcription Initiation From Type 3 Promoter  REACT_571  
RNA Polymerase III Transcription Termination  REACT_63  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: POLR1D
GenomeRNAi: 51082
PRO: PR:Q9Y2S0