AXIN2 - Axin-2 - human protein (Function)
 
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AXIN2 »  Axin-2
 
Protein also known as:  Axis inhibition protein 2.
Gene name:  AXIN2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B (By similarity).  
1
  • UniProtKB
GO molecular function 
Armadillo repeat domain bindingdefinition[GO:0070016]  
1
  • RefGenome
Beta-catenin bindingdefinition[GO:0008013]  
2
  • BHF-UCL
  • RefGenome
Enzyme bindingdefinition[GO:0019899]  
3
  • UniProtKB
GTPase activator activitydefinition[GO:0005096]  
1
  • RefGenome
I-SMAD bindingdefinition[GO:0070411] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
2
  • IntAct
Protein kinase bindingdefinition[GO:0019901]  
1
  • RefGenome
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
1
  • UniProtKB
GO biological process 
Bone mineralizationdefinition[GO:0030282] silver  
1
  • Ortholog Compara
Cell proliferationdefinition[GO:0008283] silver  
1
  • Ortholog Compara
Cellular protein localizationdefinition[GO:0034613]  
1
  • BHF-UCL
Cellular response to organic cyclic compounddefinition[GO:0071407]  
1
  • RefGenome
Chondrocyte differentiation involved in endochondral bone morphogenesisdefinition[GO:0003413] silver  
1
  • Ortholog Compara
Dorsal/ventral axis specificationdefinition[GO:0009950]  
1
  • RefGenome
Intramembranous ossificationdefinition[GO:0001957]  
1
  • RefGenome
Maintenance of DNA repeat elementsdefinition[GO:0043570]  
1
  • BHF-UCL
mRNA stabilizationdefinition[GO:0048255]  
1
  • BHF-UCL
Negative regulation of canonical Wnt signaling pathwaydefinition[GO:0090090]  
3
  • BHF-UCL
Negative regulation of catenin import into nucleusdefinition[GO:0035414]  
1
  • BHF-UCL
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • BHF-UCL
Negative regulation of osteoblast differentiationdefinition[GO:0045668]  
1
  • RefGenome
Odontogenesisdefinition[GO:0042476]  
2
  • BHF-UCL
Positive regulation of cell deathdefinition[GO:0010942]  
1
  • BHF-UCL
Positive regulation of epithelial to mesenchymal transitiondefinition[GO:0010718]  
1
  • BHF-UCL
Positive regulation of GTPase activitydefinition[GO:0043547]  
1
  • RefGenome
Positive regulation of protein phosphorylationdefinition[GO:0001934]  
1
  • BHF-UCL
Regulation of centromeric sister chromatid cohesiondefinition[GO:0070602]  
1
  • BHF-UCL
Regulation of chondrocyte developmentdefinition[GO:0061181] silver  
1
  • Ortholog Compara
Regulation of mismatch repairdefinition[GO:0032423]  
1
  • BHF-UCL
Secondary heart field specificationdefinition[GO:0003139] silver  
1
  • Ortholog Compara
Termination of G-protein coupled receptor signaling pathwaydefinition[GO:0038032] silver  
1
  • InterPro 2 GO
Wnt signaling pathway involved in somitogenesisdefinition[GO:0090244]  
1
  • RefGenome
Pathways 
According to KEGG, this protein belongs to the following pathways:
Basal cell carcinoma  hsa05217+8313  
Colorectal cancer  hsa05210+8313  
Endometrial cancer  hsa05213+8313  
Pathways in cancer  hsa05200+8313  
Wnt signaling pathway  hsa04310+8313  
According to Reactome, this protein belongs to the following pathways:
binding of TCF/LEF:CTNNB1 to target gene promoters  REACT_200799  
degradation of AXIN  REACT_200766  
TCF dependent signaling in response to WNT  REACT_200777  
 

Keywords

Biological process 
Wnt signaling pathway  definition   [KW-0879]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: AXIN2
GenomeRNAi: 8313
PRO: PR:Q9Y2T1