MAP3K2 - Mitogen-activated protein kinase kinase kinase 2 - human protein (Function)
 
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MAP3K2 »  Mitogen-activated protein kinase kinase kinase 2   [ EC 2.7.11.25 ]
 
Protein also known as:  MAPK/ERK kinase kinase 2 (MEKK 2).
Gene name:  MAP3K2
Entry whose protein(s) existence is based on evidence at protein level
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1 52 1
GENE REF ISO

Function

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Overview 
Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics.  
2
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
MAP kinase kinase kinase activitydefinition[GO:0004709]  
  • IEAEC 2 GO
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein kinase activitydefinition[GO:0004672]  
1
  • IDAMGI
Protein kinase bindingdefinition[GO:0019901]  
1
  • IPIUniProtKB
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • TASPINC
GO biological process 
Activation of JUN kinase activitydefinition[GO:0007257]  
1
  • TASPINC
Activation of MAPK activitydefinition[GO:0000187]  
1
  • TASPINC
Activation of MAPKK activitydefinition[GO:0000186] silver  
  • IEAOrtholog Compara
Cellular response to mechanical stimulusdefinition[GO:0071260]  
1
  • IEPUniProtKB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IDAUniProtKB
Protein phosphorylationdefinition[GO:0006468] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.25: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium.  
  • CuratedUniProtKB
It is regulated in the following manner
Activated by phosphorylation on Thr-524 (By similarity).  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Gap junction  hsa04540+10746  
GnRH signaling pathway  hsa04912+10746  
MAPK signaling pathway  hsa04010+10746  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: MAP3K2
GenomeRNAi: 10746
PRO: PR:Q9Y2U5
Chemistry
GuidetoPHARMACOLOGY: 2077