LEMD3 - Inner nuclear membrane protein Man1 - human protein (Function)
 
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LEMD3 »  Inner nuclear membrane protein Man1
 
Protein also known as:  LEM domain-containing protein 3.
Gene name:  LEMD3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 39 1
GENE REF ISO

Function

 show evidences
Overview 
Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest.  
2
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
  • IEAUniProtKB KW
Nucleotide bindingdefinition[GO:0000166] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
GO biological process 
Negative regulation of activin receptor signaling pathwaydefinition[GO:0032926]  
1
  • IDAUniProtKB
Negative regulation of BMP signaling pathwaydefinition[GO:0030514]  
1
  • IDAUniProtKB
Negative regulation of transforming growth factor beta receptor signaling pathwaydefinition[GO:0030512]  
1
  • IDAUniProtKB
Regulation of cell cycledefinition[GO:0051726] silver  
  • IEAOrtholog Compara
Skeletal muscle cell differentiationdefinition[GO:0035914] silver  
  • IEAOrtholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathways:
Clearance of Nuclear Envelope Membranes from Chromatin  REACT_160251  
Depolymerisation of the Nuclear Lamina  REACT_200828  
Initiation of Nuclear Envelope Reformation  REACT_160242  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 23592
PRO: PR:Q9Y2U8