GIT1 - ARF GTPase-activating protein GIT1 - human protein (Function)
 
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GIT1 »  ARF GTPase-activating protein GIT1  (ARF GAP GIT1)
 
Protein also known as:  Cool-associated and tyrosine-phosphorylated protein 1 (CAT1).
Gene name:  GIT1
Entry whose protein(s) existence is based on evidence at protein level
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1 63 3
GENE REF ISO

Function

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Overview 
GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine-phosphorylated paxillin in cytoplasmic complexes.  
1
  • CuratedUniProtKB
GO molecular function 
ARF GTPase activator activitydefinition[GO:0008060] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
9
  • IPIIntAct
  • IPIUniProtKB
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Regulation of ARF GTPase activitydefinition[GO:0032312] silver  
  • IEAInterPro 2 GO
Regulation of G-protein coupled receptor protein signaling pathwaydefinition[GO:0008277]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Endocytosis  hsa04144+28964  
Epithelial cell signaling in Helicobacter pylori infection  hsa05120+28964  
Regulation of actin cytoskeleton  hsa04810+28964  
 

Keywords

Molecular function 
GTPase activation  definition   [KW-0343]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GIT1
GenomeRNAi: 28964
PRO: PR:Q9Y2X7