HCN4 - Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 - human protein (Function)
 
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HCN4 »  Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
 
Gene name:  HCN4
Family name: Potassium channel HCN
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) that regulate the rhythm of heart beat. May contribute to the native pacemaker currents in neurons (Ih). May mediate responses to sour stimuli.  
6
  • UniProtKB
According to TCDB this is a transporter from familys:
the voltage-gated ion channel (vic) superfamily  1.A.1.5.11  
the voltage-gated ion channel (vic) superfamily  1.A.1.5.10  
GO molecular function 
cAMP bindingdefinition[GO:0030552]  
1
  • UniProtKB KW
Cation channel activitydefinition[GO:0005261]  
1
  • PINC
Identical protein bindingdefinition[GO:0042802]  
1
  • IntAct
Intracellular cAMP activated cation channel activitydefinition[GO:0005222]  
1
  • UniProtKB
Voltage-gated potassium channel activitydefinition[GO:0005249]  
3
  • UniProtKB
  • RefGenome
Voltage-gated sodium channel activitydefinition[GO:0005248]  
1
  • UniProtKB
GO biological process 
Blood circulationdefinition[GO:0008015]  
1
  • PINC
Cation transportdefinition[GO:0006812]  
1
  • PINC
Cellular response to cAMPdefinition[GO:0071320]  
2
  • UniProtKB
Cellular response to cGMPdefinition[GO:0071321]  
1
  • UniProtKB
In utero embryonic developmentdefinition[GO:0001701] silver  
1
  • Ortholog Compara
Muscle contractiondefinition[GO:0006936]  
1
  • PINC
Potassium ion transmembrane transportdefinition[GO:0071805]  
3
  • UniProtKB
  • RefGenome
Regulation of heart ratedefinition[GO:0002027]  
1
  • UniProtKB
Regulation of ion transmembrane transportdefinition[GO:0034765]  
1
  • UniProtKB KW
Regulation of membrane potentialdefinition[GO:0042391]  
2
  • UniProtKB
  • RefGenome
Sodium ion transmembrane transportdefinition[GO:0035725]  
1
  • UniProtKB
Enzymatic activity 
It is regulated in the following manner
Activated by cAMP. CAMP binding causes a conformation change that leads to the assembly of an active tetramer and channel opening.  
4
  • UniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
HCN channels  REACT_75862  
Note 
Inhibited by extracellular cesium ions.  
1
  • UniProtKB
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Sodium transport  definition   [KW-0739]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Ligand-gated ion channel  definition   [KW-1071]
Potassium channel  definition   [KW-0631]
Sodium channel  definition   [KW-0894]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: HCN4
GenomeRNAi: 10021
PRO: PR:Q9Y3Q4
Chemistry
GuidetoPHARMACOLOGY: 403