HCN4 - Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
HCN4 »  Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
 
Gene name:  HCN4
Family name: Potassium channel HCN
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 52 1
GENE REF ISO

Function

 show evidences
Overview 
Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) that regulate the rhythm of heart beat. May contribute to the native pacemaker currents in neurons (Ih). May mediate responses to sour stimuli.  
5
  • CuratedUniProtKB
According to TCDB this is a transporter from familys:
the voltage-gated ion channel (vic) superfamily  1.A.1.5.11  
the voltage-gated ion channel (vic) superfamily  1.A.1.5.10  
GO molecular function 
cAMP bindingdefinition[GO:0030552]  
  • IEAUniProtKB KW
Cation channel activitydefinition[GO:0005261]  
1
  • TASPINC
Identical protein bindingdefinition[GO:0042802]  
1
  • IPIIntAct
Intracellular cAMP activated cation channel activitydefinition[GO:0005222]  
1
  • IDAUniProtKB
Voltage-gated potassium channel activitydefinition[GO:0005249]  
2
  • IMPUniProtKB
  • IBARefGenome
Voltage-gated sodium channel activitydefinition[GO:0005248]  
1
  • IMPUniProtKB
GO biological process 
Blood circulationdefinition[GO:0008015]  
1
  • NASPINC
Cation transportdefinition[GO:0006812]  
1
  • TASPINC
Cellular response to cAMPdefinition[GO:0071320]  
2
  • IDAUniProtKB
Cellular response to cGMPdefinition[GO:0071321]  
1
  • IDAUniProtKB
In utero embryonic developmentdefinition[GO:0001701] silver  
  • IEAOrtholog Compara
Muscle contractiondefinition[GO:0006936]  
1
  • TASPINC
Potassium ion transmembrane transportdefinition[GO:0071805]  
2
  • IMPUniProtKB
  • IBARefGenome
Regulation of heart ratedefinition[GO:0002027]  
1
  • IMPUniProtKB
Regulation of membrane potentialdefinition[GO:0042391]  
1
  • IMPUniProtKB
  • IBARefGenome
Sodium ion transmembrane transportdefinition[GO:0035725]  
1
  • IMPUniProtKB
Enzymatic activity 
It is regulated in the following manner
Activated by cAMP. CAMP binding causes a conformation change that leads to the assembly of an active tetramer and channel opening.  
3
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Neuronal System  REACT_13685  
Note 
Inhibited by extracellular cesium ions.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Sodium transport  definition   [KW-0739]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Ligand-gated ion channel  definition   [KW-1071]
Potassium channel  definition   [KW-0631]
Sodium channel  definition   [KW-0894]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: HCN4
GenomeRNAi: 10021
PRO: PR:Q9Y3Q4
Chemistry
GuidetoPHARMACOLOGY: 403