SAMHD1 - Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 - human protein (Function)
 
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SAMHD1 »  Deoxynucleoside triphosphate triphosphohydrolase SAMHD1   [ EC 3.1.5.- ]  (dNTPase)
 
Protein also known as:  SAM domain and HD domain-containing protein 1.
Gene name:  SAMHD1
Family name: SAMHD1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
Overview 
Host restriction nuclease that blocks early-stage virus replication in dendritic and other myeloid cells. May function by reducing the cellular dNTP levels to levels too low for retroviral reverse transcription to occur. May play a role in mediating proinflammatory responses to TNF-alpha signaling.  
3
  • CuratedUniProtKB
GO molecular function 
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Nucleic acid bindingdefinition[GO:0003676]  
1
  • IDAUniProtKB
Phosphoric diester hydrolase activitydefinition[GO:0008081] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
RNA bindingdefinition[GO:0003723]  
1
  • IDAUniProtKB
GO biological process 
Defense response to virusdefinition[GO:0051607]  
1
  • IMPUniProtKB
Immune responsedefinition[GO:0006955]  
1
  • NASUniProtKB
Innate immune responsedefinition[GO:0045087]  
  • IEAUniProtKB KW
Regulation of innate immune responsedefinition[GO:0045088]  
1
  • IMPUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.5.-: dNTP + H(2)O Deoxynucleoside + triphosphate.  
1
  • CuratedUniProtKB
It is regulated in the following manner
Allosterically stimulated by dGTP which binds in a cleft at the interface of the homodimer.  
1
  • CuratedUniProtKB
 

Keywords

Biological process 
Antiviral defense  definition   [KW-0051]
Immunity  definition   [KW-0391]
Innate immunity  definition   [KW-0399]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SAMHD1
GenomeRNAi: 25939
PRO: PR:Q9Y3Z3