SAMHD1 - Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 - human protein (Function)
 
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SAMHD1 »  Deoxynucleoside triphosphate triphosphohydrolase SAMHD1   [ EC 3.1.5.- ]  (dNTPase)
 
Protein also known as:  SAM domain and HD domain-containing protein 1.
Gene name:  SAMHD1
Family name: SAMHD1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Host restriction nuclease that blocks early-stage virus replication in dendritic and other myeloid cells. Likewise, suppresses LINE-1 retrotransposon activity. May function by reducing the cellular dNTP levels to levels too low for retroviral reverse transcription to occur. May play a role in mediating proinflammatory responses to TNF-alpha signaling.  
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  • UniProtKB
GO molecular function 
dGTP bindingdefinition[GO:0032567]  
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  • UniProtKB
dGTPase activitydefinition[GO:0008832]  
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  • UniProtKB
Nucleic acid bindingdefinition[GO:0003676]  
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  • UniProtKB
Protein bindingdefinition[GO:0005515]  
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  • IntAct
RNA bindingdefinition[GO:0003723]  
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  • UniProtKB
Zinc ion bindingdefinition[GO:0008270]  
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  • UniProtKB
GO biological process 
dATP catabolic processdefinition[GO:0046061]  
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  • UniProtKB
Defense response to virusdefinition[GO:0051607]  
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  • UniProtKB
dGTP catabolic processdefinition[GO:0006203]  
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  • UniProtKB
Immune responsedefinition[GO:0006955]  
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  • UniProtKB
Innate immune responsedefinition[GO:0045087]  
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  • UniProtKB KW
Protein homotetramerizationdefinition[GO:0051289]  
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  • UniProtKB
Regulation of innate immune responsedefinition[GO:0045088]  
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  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.5.-: dNTP + H(2)O Deoxynucleoside + triphosphate.  
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  • UniProtKB
It requires the following cofactor
 Zn(2+) : Binds 1 zinc ion per subunit.  
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  • UniProtKB
It is regulated in the following manner
Allosterically stimulated by dGTP which binds in a cleft at the interface of the homodimer and promotes the formation of highly active homotetramers. Each allosteric site binds two molecules of dGTP (dGTP1 and dGTP 2) between adjoining subunits. Not activated by dATP, dCTP and dTTP.  
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  • UniProtKB
 

Keywords

Biological process 
Antiviral defense  definition   [KW-0051]
Immunity  definition   [KW-0391]
Innate immunity  definition   [KW-0399]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Allosteric enzyme  definition   [KW-0021]
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SAMHD1
GenomeRNAi: 25939
PRO: PR:Q9Y3Z3