SAMHD1 - Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 - human protein (Function)
 
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SAMHD1 »  Deoxynucleoside triphosphate triphosphohydrolase SAMHD1   [ EC 3.1.5.- ]  (dNTPase)
 
Protein also known as:  SAM domain and HD domain-containing protein 1.
Gene name:  SAMHD1
Family name: SAMHD1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

 show evidences
Overview 
Host restriction nuclease that blocks early-stage virus replication in dendritic and other myeloid cells. Likewise, suppresses LINE-1 retrotransposon activity. May function by reducing the cellular dNTP levels to levels too low for retroviral reverse transcription to occur. May play a role in mediating proinflammatory responses to TNF-alpha signaling.  
4
  • CuratedUniProtKB
GO molecular function 
dGTP bindingdefinition[GO:0032567]  
1
  • IDAUniProtKB
dGTPase activitydefinition[GO:0008832]  
1
  • IDAUniProtKB
Nucleic acid bindingdefinition[GO:0003676]  
1
  • IDAUniProtKB
Phosphoric diester hydrolase activitydefinition[GO:0008081] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
RNA bindingdefinition[GO:0003723]  
1
  • IDAUniProtKB
Zinc ion bindingdefinition[GO:0008270]  
1
  • IDAUniProtKB
GO biological process 
dATP catabolic processdefinition[GO:0046061]  
1
  • IDAUniProtKB
Defense response to virusdefinition[GO:0051607]  
1
  • IMPUniProtKB
dGTP catabolic processdefinition[GO:0006203]  
1
  • IDAUniProtKB
Immune responsedefinition[GO:0006955]  
1
  • NASUniProtKB
Innate immune responsedefinition[GO:0045087]  
  • IEAUniProtKB KW
Protein homotetramerizationdefinition[GO:0051289]  
1
  • IDAUniProtKB
Regulation of innate immune responsedefinition[GO:0045088]  
1
  • IMPUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.5.-: dNTP + H(2)O Deoxynucleoside + triphosphate.  
2
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 zinc ion per subunit.  
1
  • CuratedUniProtKB
It is regulated in the following manner
Allosterically stimulated by dGTP which binds in a cleft at the interface of the homodimer and promotes the formation of highly active homotetramers. Each allosteric site binds two molecules of dGTP (dGTP1 and dGTP 2) between adjoining subunits. Not activated by dATP, dCTP and dTTP.  
3
  • CuratedUniProtKB
 

Keywords

Biological process 
Antiviral defense  definition   [KW-0051]
Immunity  definition   [KW-0391]
Innate immunity  definition   [KW-0399]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Allosteric enzyme  definition   [KW-0021]
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SAMHD1
GenomeRNAi: 25939
PRO: PR:Q9Y3Z3