DYRK1B - Dual specificity tyrosine-phosphorylation-regulated kinase 1B - human protein (Function)
 
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DYRK1B »  Dual specificity tyrosine-phosphorylation-regulated kinase 1B   [ EC 2.7.12.1 ]
 
Protein also known as:  Minibrain-related kinase.
Gene name:  DYRK1B
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

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Overview 
Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase (G6PC).  
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  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
5
  • IntAct
  • UniProtKB
Protein kinase activitydefinition[GO:0004672]  
1
  • UniProtKB
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • UniProtKB KW
Protein serine/threonine/tyrosine kinase activitydefinition[GO:0004712]  
1
  • EC 2 GO
Protein tyrosine kinase activitydefinition[GO:0004713]  
1
  • UniProtKB KW
Transcription coactivator activitydefinition[GO:0003713]  
1
  • UniProtKB
GO biological process 
Adipose tissue developmentdefinition[GO:0060612]  
1
  • UniProtKB
Myoblast fusiondefinition[GO:0007520] silver  
1
  • Ortholog Compara
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
1
  • UniProtKB KW
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • UniProtKB
Protein phosphorylationdefinition[GO:0006468]  
1
  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.12.1: ATP + a protein ADP + a phosphoprotein.  
2
  • UniProtKB
It is regulated in the following manner
Inhibited by RANBP9.  
1
  • UniProtKB
 
More information is available from:
Pathways 
 
More information is available from:
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: DYRK1B
GenomeRNAi: 9149
PRO: PR:Q9Y463
Chemistry
GuidetoPHARMACOLOGY: 2010