CMAHP - Putative cytidine monophosphate-N-acetylneuraminic acid hydroxylase-like protein - human protein (Function)
 
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CMAHP »  Putative cytidine monophosphate-N-acetylneuraminic acid hydroxylase-like protein  (CMP-NeuAc hydroxylase-like protein)
 
Protein also known as:  Cytidine monophosphate-N-acetylneuraminic acid hydroxylase pseudogene.
Gene name:  CMAHP
Family name: CMP-Neu5Ac hydroxylase
Entry whose protein(s) existence is uncertain. Could be the product of a pseudogene. An Alu-mediated inactivating mutation of this gene occured in common ancestors of humans and Neanderthals approximately 2.1-2.2 million years ago, before brain expansion. The resulting product is a truncated and most probably inactive enzyme explaining the absence CMP-Neu5Gc sialic acid in human, while it is abundantly expressed at the surface of many cells in other vertebrates (PubMed:9751737 and PubMed:12192086).
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GENE REF ISO

Function

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GO molecular function 
2 iron, 2 sulfur cluster bindingdefinition[GO:0051537] silver  
  • IEAInterPro 2 GO
Not  CMP-N-acetylneuraminate monooxygenase activitydefinition[GO:0030338]  
1
  • NASUniProtKB
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]