ATP6V0A2 - V-type proton ATPase 116 kDa subunit a isoform 2 - human protein (Function)
 
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ATP6V0A2 »  V-type proton ATPase 116 kDa subunit a isoform 2  (V-ATPase 116 kDa isoform a2)
 
Protein also known as:  Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2.
Gene name:  ATP6V0A2
Entry whose protein(s) existence is based on evidence at protein level
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1 37 1
GENE REF ISO

Function

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Overview 
Part of the proton channel of V-ATPases. Essential component of the endosomal pH-sensing machinery. May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH.  
2
  • CuratedUniProtKB
GO molecular function 
Hydrogen ion transmembrane transporter activitydefinition[GO:0015078] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
GO biological process 
ATP hydrolysis coupled proton transportdefinition[GO:0015991] silver  
  • IEAInterPro 2 GO
Immune responsedefinition[GO:0006955]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Collecting duct acid secretion  hsa04966+23545  
Epithelial cell signaling in Helicobacter pylori infection  hsa05120+23545  
Lysosome  hsa04142+23545  
Metabolic pathways  hsa01100+23545  
Oxidative phosphorylation  hsa00190+23545  
Phagosome  hsa04145+23545  
Rheumatoid arthritis  hsa05323+23545  
Synaptic vesicle cycle  hsa04721+23545  
Tuberculosis  hsa05152+23545  
Vibrio cholerae infection  hsa05110+23545  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Signal Transduction  REACT_111102  
Transmembrane transport of small molecules  REACT_15518  
 
More information is available from:
Caution 
The N-terminus peptide may increase IL1B secretion by peripheral blood monocytes; however as this region is probably in the cytosol, the in vivo relevance of this observation needs to be confirmed.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Hydrogen ion transport  definition   [KW-0375]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ATP6V0A2
GenomeRNAi: 23545
PRO: PR:Q9Y487