DAGLA - Sn1-specific diacylglycerol lipase alpha - human protein (Function)
 
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Protein
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References

 
DAGLA »  Sn1-specific diacylglycerol lipase alpha   [ EC 3.1.1.- ]  (DGL-alpha)
 
Protein also known as:  Neural stem cell-derived dendrite regulator.
Gene name:  DAGLA
Family name: AB hydrolase » Lipase
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.  
1
  • CuratedUniProtKB
GO molecular function 
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Triglyceride lipase activitydefinition[GO:0004806] silver  
  • IEAInterPro 2 GO
GO biological process 
Arachidonic acid metabolic processdefinition[GO:0019369]  
1
  • IDAUniProtKB
Cell deathdefinition[GO:0008219]  
  • IEAUniProtKB KW
Diacylglycerol catabolic processdefinition[GO:0046340]  
1
  • IDAUniProtKB
Endocannabinoid signaling pathwaydefinition[GO:0071926] silver  
  • IEAOrtholog Compara
Neuroblast proliferationdefinition[GO:0007405] silver  
  • IEAOrtholog Compara
Neurotransmitter biosynthetic processdefinition[GO:0042136]  
1
  • IDAUniProtKB
Enzymatic activity 
It requires the following cofactor
Calcium.  
1
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by p-hydroxy-mercuri-benzoate and HgCl(2), but not to PMSF. Also inhibited by RHC80267, a drug that blocks 2-AG formation.  
1
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathways:
Hemostasis  REACT_604  
Signal Transduction  REACT_111102  
 

Biophysicochemical properties

Kinetic parameters
KM 154.7 uM for diacylglycerol
Vmax 33.3 nmol/min/mg enzyme
Dependence
pH Optimum pH is 7.0.

Keywords

Biological process 
Lipid degradation  definition   [KW-0442]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GenomeRNAi: 747
PRO: PR:Q9Y4D2
Chemistry
GuidetoPHARMACOLOGY: 1396