FAM21C - WASH complex subunit FAM21C - human protein (Function)
 
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FAM21C »  WASH complex subunit FAM21C
 
Protein also known as:  Vaccinia virus penetration factor (VPEF).
Gene name:  FAM21C
Family name: FAM21
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting. In the complex, it probably mediates the recruitment of the complex to endosome membranes. Plays a role in fluid-phase endocytosis, a process exploited by vaccinia intracellular mature virus (IMV) to enter cells. As a result, may facilitate the penetration of IMV into cells.  
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  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
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  • IPIUniProtKB
GO biological process 
Retrograde transport, endosome to Golgidefinition[GO:0042147]  
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  • IMPUniProtKB
Note 
In human, FAM21 has undergone evolutionary duplication, with 4 highly homologous family members existing, including FAM21A, FAM21B, FAM21C, and an N-terminally truncated FAM21D form.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FAM21C
GenomeRNAi: 253725
PRO: PR:Q9Y4E1