RNF115 - E3 ubiquitin-protein ligase RNF115 - human protein (Function)
 
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RNF115 »  E3 ubiquitin-protein ligase RNF115   [ EC 6.3.2.- ]
 
Protein also known as:  RING finger protein 115.
Gene name:  RNF115
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
E3 ubiquitin-protein ligase that mediates E2-dependent, 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of substrates and may play a role in diverse biological processes. Through their polyubiquitination, may play a role in the endosomal trafficking and degradation of membrane receptors including EGFR, FLT3, MET and CXCR4.  
4
  • UniProtKB
GO molecular function 
Ligase activitydefinition[GO:0016874]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • UniProtKB
Ubiquitin protein ligase activitydefinition[GO:0061630]  
1
  • Ortholog Curator
Ubiquitin-protein transferase activitydefinition[GO:0004842]  
1
  • UniProtKB
Zinc ion bindingdefinition[GO:0008270] silver  
1
  • InterPro 2 GO
GO biological process 
Negative regulation of epidermal growth factor receptor signaling pathwaydefinition[GO:0042059]  
1
  • UniProtKB
Protein autoubiquitinationdefinition[GO:0051865]  
1
  • UniProtKB
Protein K48-linked ubiquitinationdefinition[GO:0070936]  
1
  • Ortholog Curator
Protein K63-linked ubiquitinationdefinition[GO:0070534]  
1
  • Ortholog Curator
Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathwaydefinition[GO:0043162]  
1
  • UniProtKB
Pathways 
This protein is involved in the following pathway
Protein modification; protein ubiquitination  
2
  • UniProtKB
 

Keywords

Biological process 
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ZNF364
GenomeRNAi: 27246
PRO: PR:Q9Y4L5