AFG3L2 - AFG3-like protein 2 - human protein (Function)
 
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AFG3L2 »  AFG3-like protein 2   [ EC 3.4.24.- ]
 
Protein also known as:  Paraplegin-like protein.
Gene name:  AFG3L2
Family names: In the N-terminal section AAA ATPase
In the C-terminal section Peptidase M41
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 26 1
GENE REF ISO

Function

 show evidences
Overview 
ATP-dependent protease which is essential for axonal development (By similarity).  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Metalloendopeptidase activitydefinition[GO:0004222] silver  
  • IEAInterPro 2 GO
Nucleoside-triphosphatase activitydefinition[GO:0017111] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Unfolded protein bindingdefinition[GO:0051082]  
1
  • TASPINC
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Axonogenesisdefinition[GO:0007409] silver  
  • IEAOrtholog Compara
Cell deathdefinition[GO:0008219]  
  • IEAUniProtKB KW
Cristae formationdefinition[GO:0042407] silver  
  • IEAOrtholog Compara
Mitochondrial fusiondefinition[GO:0008053] silver  
  • IEAOrtholog Compara
Mitochondrial protein processingdefinition[GO:0034982] silver  
  • IEAOrtholog Compara
Muscle fiber developmentdefinition[GO:0048747] silver  
  • IEAOrtholog Compara
Myelinationdefinition[GO:0042552] silver  
  • IEAOrtholog Compara
Nerve developmentdefinition[GO:0021675] silver  
  • IEAOrtholog Compara
Neuromuscular junction developmentdefinition[GO:0007528] silver  
  • IEAOrtholog Compara
Proteolysisdefinition[GO:0006508]  
  • IEAUniProtKB KW
Regulation of multicellular organism growthdefinition[GO:0040014] silver  
  • IEAOrtholog Compara
Righting reflexdefinition[GO:0060013] silver  
  • IEAOrtholog Compara
Enzymatic activity 
It requires the following cofactor
Binds 1 zinc ion per subunit (Potential).  
  • CuratedUniProtKB
 
More information is available from:
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: AFG3L2
GenomeRNAi: 10939
PRO: PR:Q9Y4W6