RIPK3 - Receptor-interacting serine/threonine-protein kinase 3 - human protein (Function)
 
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RIPK3 »  Receptor-interacting serine/threonine-protein kinase 3   [ EC 2.7.11.1 ]
 
Protein also known as:  Receptor-interacting protein 3 (RIP-3).
Gene name:  RIPK3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 44 3
GENE REF ISO

Function

 show evidences
Overview 
Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Identical protein bindingdefinition[GO:0042802]  
1
  • IPIIntAct
NF-kappaB-inducing kinase activitydefinition[GO:0004704] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
9
  • IPIIntAct
  • IPIUniProtKB
Protein complex bindingdefinition[GO:0032403]  
1
  • IMPUniProtKB
Protein kinase activitydefinition[GO:0004672]  
3
  • IMPUniProtKB
Protein serine/threonine kinase activitydefinition[GO:0004674]  
  • ISSOrtholog Curator
Transcription coactivator activitydefinition[GO:0003713]  
1
  • TASPINC
GO biological process 
Activation of protein kinase activitydefinition[GO:0032147]  
1
  • IMPUniProtKB
Amyloid fibril formationdefinition[GO:1990000]  
1
  • IMPUniProtKB
Apoptotic signaling pathwaydefinition[GO:0097190]  
1
  • TASPINC
Cellular protein modification processdefinition[GO:0006464]  
1
  • TASPINC
I-kappaB kinase/NF-kappaB signalingdefinition[GO:0007249] silver  
  • IEAOrtholog Compara
Lymph node developmentdefinition[GO:0048535]  
  • ISSOrtholog Curator
Necroptotic processdefinition[GO:0070266]  
2
  • IMPUniProtKB
Positive regulation of intrinsic apoptotic signaling pathwaydefinition[GO:2001244] silver  
  • IEAOrtholog Compara
Positive regulation of necroptotic processdefinition[GO:0060545]  
2
  • IMPUniProtKB
Positive regulation of NF-kappaB transcription factor activitydefinition[GO:0051092]  
1
  • IDAUniProtKB
Positive regulation of phosphatase activitydefinition[GO:0010922]  
1
  • IMPUniProtKB
Protein autophosphorylationdefinition[GO:0046777]  
1
  • IDAUniProtKB
Protein heterooligomerizationdefinition[GO:0051291]  
1
  • IMPUniProtKB
Protein homooligomerizationdefinition[GO:0051260]  
1
  • IDAUniProtKB
Regulation of activated T cell proliferationdefinition[GO:0046006]  
  • ISSOrtholog Curator
Regulation of activation-induced cell death of T cellsdefinition[GO:0070235]  
  • ISSOrtholog Curator
Regulation of adaptive immune responsedefinition[GO:0002819]  
  • ISSOrtholog Curator
Regulation of CD8-positive, alpha-beta cytotoxic T cell extravasationdefinition[GO:2000452]  
  • ISSOrtholog Curator
Regulation of interferon-gamma productiondefinition[GO:0032649]  
  • ISSOrtholog Curator
Regulation of T cell mediated cytotoxicitydefinition[GO:0001914]  
  • ISSOrtholog Curator
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Spleen developmentdefinition[GO:0048536]  
  • ISSOrtholog Curator
T cell differentiation in thymusdefinition[GO:0033077]  
  • ISSOrtholog Curator
T cell homeostasisdefinition[GO:0043029]  
  • ISSOrtholog Curator
Thymus developmentdefinition[GO:0048538]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Cytosolic DNA-sensing pathway  hsa04623+11035  
According to Reactome, this protein belongs to the following pathway:
Immune System  REACT_6900  
 

Keywords

Biological process 
Necrosis  definition   [KW-1210]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: RIPK3
GenomeRNAi: 11035
PRO: PR:Q9Y572