CLDN16 - Claudin-16 - human protein (Function)
 
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Protein
Gene
References

 
CLDN16 »  Claudin-16
 
Protein also known as:  Paracellin-1 (PCLN-1).
Gene name:  CLDN16
Family name: Claudin
Entry whose protein(s) existence is based on evidence at protein level
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1 32 1
GENE REF ISO

Function

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Overview 
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Involved in paracellular magnesium reabsorption. Required for a selective paracellular conductance. May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients. Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the claudin tight junction (claudin) family  1.H.1.1.1  
GO molecular function 
Identical protein bindingdefinition[GO:0042802]  
  • ISSOrtholog Curator
Magnesium ion transmembrane transporter activitydefinition[GO:0015095]  
1
  • TASPINC
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Structural molecule activitydefinition[GO:0005198] silver  
  • IEAInterPro 2 GO
GO biological process 
Calcium-independent cell-cell adhesiondefinition[GO:0016338]  
  • ISSOrtholog Curator
Cellular metal ion homeostasisdefinition[GO:0006875]  
1
  • TASPINC
Excretiondefinition[GO:0007588]  
1
  • TASPINC
Magnesium ion transportdefinition[GO:0015693]  
1
  • TASGOC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cell adhesion molecules (CAMs)  hsa04514+10686  
Hepatitis C  hsa05160+10686  
Leukocyte transendothelial migration  hsa04670+10686  
Tight junction  hsa04530+10686  
According to Reactome, this protein belongs to the following pathway:
Tight junction interactions  REACT_19373  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CLDN16
GenomeRNAi: 10686
PRO: PR:Q9Y5I7