CD2AP - CD2-associated protein - human protein (Function)
 
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CD2AP »  CD2-associated protein
 
Protein also known as:  Cas ligand with multiple SH3 domains.
Gene name:  CD2AP
Entry whose protein(s) existence is based on evidence at protein level
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1 85 1
GENE REF ISO

Function

 show evidences
Overview 
Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation. May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis.  
2
  • UniProtKB
GO molecular function 
Beta-catenin bindingdefinition[GO:0008013] silver  
1
  • Ortholog Compara
Cadherin bindingdefinition[GO:0045296] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
10
  • IntAct
  • UniProtKB
Protein C-terminus bindingdefinition[GO:0008022] silver  
1
  • Ortholog Compara
Protein complex bindingdefinition[GO:0032403] silver  
1
  • Ortholog Compara
SH3 domain bindingdefinition[GO:0017124]  
1
  • UniProtKB
Structural constituent of cytoskeletondefinition[GO:0005200]  
1
  • PINC
Vascular endothelial growth factor receptor bindingdefinition[GO:0005172] silver  
1
  • Ortholog Compara
GO biological process 
Cell divisiondefinition[GO:0051301]  
1
  • UniProtKB KW
Mitotic nuclear divisiondefinition[GO:0007067]  
1
  • UniProtKB KW
Negative regulation of transforming growth factor beta1 productiondefinition[GO:0032911] silver  
1
  • Ortholog Compara
Positive regulation of protein localization to nucleusdefinition[GO:1900182] silver  
1
  • Ortholog Compara
Proteasome-mediated ubiquitin-dependent protein catabolic processdefinition[GO:0043161] silver  
1
  • Ortholog Compara
Protein complex assemblydefinition[GO:0006461]  
1
  • PINC
Regulation of actin cytoskeleton reorganizationdefinition[GO:2000249] silver  
1
  • Ortholog Compara
Regulation of receptor-mediated endocytosisdefinition[GO:0048259] silver  
1
  • Ortholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • PINC
Single organismal cell-cell adhesiondefinition[GO:0016337] silver  
1
  • Ortholog Compara
Substrate-dependent cell migration, cell extensiondefinition[GO:0006930]  
1
  • PINC
Vesicle organizationdefinition[GO:0016050] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Bacterial invasion of epithelial cells  hsa05100+23607  
According to Reactome, this protein belongs to the following pathway:
Nephrin interactions  R-HSA-373753  
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Cell division  definition   [KW-0132]
Mitosis  definition   [KW-0498]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CD2AP
GenomeRNAi: 23607
PRO: PR:Q9Y5K6