CD2AP - CD2-associated protein - human protein (Function)
 
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CD2AP »  CD2-associated protein
 
Protein also known as:  Cas ligand with multiple SH3 domains.
Gene name:  CD2AP
Entry whose protein(s) existence is based on evidence at protein level
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1 71 1
GENE REF ISO

Function

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Overview 
Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation. May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis.  
1
  • CuratedUniProtKB
GO molecular function 
Beta-catenin bindingdefinition[GO:0008013] silver  
  • IEAOrtholog Compara
Cadherin bindingdefinition[GO:0045296] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
9
  • IPIIntAct
  • IPIUniProtKB
Protein C-terminus bindingdefinition[GO:0008022] silver  
  • IEAOrtholog Compara
Protein complex bindingdefinition[GO:0032403] silver  
  • IEAOrtholog Compara
SH3 domain bindingdefinition[GO:0017124]  
1
  • IPIUniProtKB
Structural constituent of cytoskeletondefinition[GO:0005200]  
1
  • TASPINC
Vascular endothelial growth factor receptor bindingdefinition[GO:0005172] silver  
  • IEAOrtholog Compara
GO biological process 
Cell-cell adhesiondefinition[GO:0016337] silver  
  • IEAOrtholog Compara
Mitosisdefinition[GO:0007067]  
  • IEAUniProtKB KW
Proteasome-mediated ubiquitin-dependent protein catabolic processdefinition[GO:0043161] silver  
  • IEAOrtholog Compara
Protein complex assemblydefinition[GO:0006461]  
1
  • TASPINC
Regulation of receptor-mediated endocytosisdefinition[GO:0048259] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • NASPINC
Substrate-dependent cell migration, cell extensiondefinition[GO:0006930]  
1
  • TASPINC
Vesicle organizationdefinition[GO:0016050] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Bacterial invasion of epithelial cells  hsa05100+23607  
According to Reactome, this protein belongs to the following pathway:
Cell-Cell communication  REACT_111155  
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Cell division  definition   [KW-0132]
Mitosis  definition   [KW-0498]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CD2AP
GenomeRNAi: 23607
PRO: PR:Q9Y5K6