MAFB - Transcription factor MafB - human protein (Function)
 
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MAFB »  Transcription factor MafB  (Maf-B)
 
Protein also known as:  V-maf musculoaponeurotic fibrosarcoma oncogene homolog B.
Gene name:  MAFB
Family name: bZIP » Maf
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 44 1
GENE REF ISO

Function

 show evidences
Overview 
Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter (By similarity). Involved either as an oncogene or as a tumor suppressor, depending on the cell context.  
2
  • UniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
2
  • IntAct
  • UniProtKB
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
1
  • InterPro 2 GO
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
1
  • InterPro 2 GO
Transcription factor bindingdefinition[GO:0008134]  
1
  • UniProtKB
GO biological process 
Brain segmentationdefinition[GO:0035284] silver  
1
  • Ortholog Compara
Inner ear morphogenesisdefinition[GO:0042472] silver  
1
  • Ortholog Compara
Negative regulation of erythrocyte differentiationdefinition[GO:0045647]  
1
  • UniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
1
  • Ortholog Compara
Respiratory gaseous exchangedefinition[GO:0007585] silver  
1
  • Ortholog Compara
Rhombomere 5 developmentdefinition[GO:0021571] silver  
1
  • Ortholog Compara
Rhombomere 6 developmentdefinition[GO:0021572] silver  
1
  • Ortholog Compara
Segment specificationdefinition[GO:0007379] silver  
1
  • Ortholog Compara
Sensory organ developmentdefinition[GO:0007423]  
1
  • PINC
T cell differentiation in thymusdefinition[GO:0033077] silver  
1
  • Ortholog Compara
Thymus developmentdefinition[GO:0048538] silver  
1
  • Ortholog Compara
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • UniProtKB KW
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MAFB_(gene)
GenomeRNAi: 9935
PRO: PR:Q9Y5Q3