MAFB - Transcription factor MafB - human protein (Function)
 
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MAFB »  Transcription factor MafB  (Maf-B)
 
Protein also known as:  V-maf musculoaponeurotic fibrosarcoma oncogene homolog B.
Gene name:  MAFB
Family name: bZIP » Maf
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter (By similarity). Involved either as an oncogene or as a tumor suppressor, depending on the cell context.  
1
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
  • IPIUniProtKB
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IEAInterPro 2 GO
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAInterPro 2 GO
Transcription factor bindingdefinition[GO:0008134]  
1
  • IDAUniProtKB
GO biological process 
Brain segmentationdefinition[GO:0035284] silver  
  • IEAOrtholog Compara
Inner ear morphogenesisdefinition[GO:0042472] silver  
  • IEAOrtholog Compara
Negative regulation of erythrocyte differentiationdefinition[GO:0045647]  
1
  • IDAUniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
Respiratory gaseous exchangedefinition[GO:0007585] silver  
  • IEAOrtholog Compara
Rhombomere 5 developmentdefinition[GO:0021571] silver  
  • IEAOrtholog Compara
Rhombomere 6 developmentdefinition[GO:0021572] silver  
  • IEAOrtholog Compara
Segment specificationdefinition[GO:0007379] silver  
  • IEAOrtholog Compara
Sensory organ developmentdefinition[GO:0007423]  
1
  • TASPINC
T cell differentiation in thymusdefinition[GO:0033077] silver  
  • IEAOrtholog Compara
Thymus developmentdefinition[GO:0048538] silver  
  • IEAOrtholog Compara
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MAFB_(gene)
GenomeRNAi: 9935
PRO: PR:Q9Y5Q3