CORIN - Atrial natriuretic peptide-converting enzyme - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
CORIN »  Atrial natriuretic peptide-converting enzyme   [ EC 3.4.21.- ]
 
Protein also known as:  Heart-specific serine proteinase ATC2. Cleaved into:  Atrial natriuretic peptide-converting enzyme, 100 kDa soluble fragment; Atrial natriuretic peptide-converting enzyme, 160 kDa soluble fragment; Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment; Atrial natriuretic peptide-converting enzyme, N-terminal propeptide; Atrial natriuretic peptide-converting enzyme, activated protease fragment.
Gene name:  CORIN
Family name: Peptidase S1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 51 2
GENE REF ISO

Function

 show evidences
Overview 
Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide.  
3
  • CuratedUniProtKB
GO molecular function 
Serine-type endopeptidase activitydefinition[GO:0004252]  
2
  • IDAUniProtKB
Serine-type exopeptidase activitydefinition[GO:0070008] silver  
  • IEAInterPro 2 GO
GO biological process 
Female pregnancydefinition[GO:0007565]  
1
  • IMPUniProtKB
Peptide hormone processingdefinition[GO:0016486]  
2
  • IDAUniProtKB
Proteolysisdefinition[GO:0006508]  
1
  • IDAGOC
  • IEAUniProtKB KW
Regulation of blood pressuredefinition[GO:0008217]  
  • ISSOrtholog Curator
Regulation of renal sodium excretiondefinition[GO:0035813]  
  • ISSOrtholog Curator
Regulation of systemic arterial blood pressure by atrial natriuretic peptidedefinition[GO:0003050]  
1
  • IMPUniProtKB
  • ISSOrtholog Curator
Enzymatic activity 
It is regulated in the following manner
Inhibited in a dose-dependent manner by non-specific trypsin-like serine protease inhibitors including benzamidine.  
  • CuratedUniProtKB
 
More information is available from:
Note 
Initially named CORIN due to its abundant expression in the heart (PubMed10329693).  
1
  • CuratedUniProtKB
 

Biophysicochemical properties

Kinetic parameters
KM 16 mM for pyroGlu-Gly-Arg-pNA.HCl
KM 2.95 mM for H-D-Pro-Phe-Arg-pNA.2HCl
KM 1.92 mM for Bz-Ile-Glu-(gamma-OR)-Gly-Arg-pNA.HCl
KM 3.52 mM for pyroGlu-Pro-Arg-pNA.HCl
KM 1.28 mM for pyroGlu-Phe-Lys-pNA.HCl

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Serine protease  definition   [KW-0720]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CORIN
GenomeRNAi: 10699
PRO: PR:Q9Y5Q5