NOX1 - NADPH oxidase 1 - human protein (Function)
 
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Protein
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References

 
NOX1 »  NADPH oxidase 1   [ EC 1.-.-.- ]  (NOX-1)
 
Protein also known as:  NADH/NADPH mitogenic oxidase subunit P65-MOX.
Gene name:  NOX1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 105 3
GENE REF ISO

Function

 show evidences
Overview 
NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the phagocyte (gp91(phox)) nadph oxidase family  5.B.1.1.3  
GO molecular function 
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
NADP bindingdefinition[GO:0050661]  
1
  • ICBHF-UCL
Protein bindingdefinition[GO:0005515]  
1
  • IPIBHF-UCL
Rac GTPase bindingdefinition[GO:0048365]  
1
  • IPIBHF-UCL
Superoxide-generating NADPH oxidase activitydefinition[GO:0016175]  
3
  • TASBHF-UCL
  • TASUniProtKB
Voltage-gated proton channel activitydefinition[GO:0030171]  
1
  • IDABHF-UCL
GO biological process 
Angiogenesisdefinition[GO:0001525]  
1
  • IMPBHF-UCL
Cell migrationdefinition[GO:0016477]  
1
  • IMPBHF-UCL
Cellular response to aciditydefinition[GO:0071468]  
1
  • IDABHF-UCL
Extracellular matrix organizationdefinition[GO:0030198] silver  
  • IEAOrtholog Compara
Hydrogen peroxide metabolic processdefinition[GO:0042743]  
1
  • IDABHF-UCL
Inflammatory responsedefinition[GO:0006954]  
1
  • TASBHF-UCL
Intracellular pH elevationdefinition[GO:0051454]  
1
  • IDABHF-UCL
Ion transmembrane transportdefinition[GO:0034220]  
1
  • IDAGOC
NADP metabolic processdefinition[GO:0006739]  
1
  • ICBHF-UCL
Oxidation-reduction processdefinition[GO:0055114]  
1
  • IDABHF-UCL
Oxygen metabolic processdefinition[GO:0072592] silver  
  • IEAOrtholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • IDABHF-UCL
Positive regulation of integrin biosynthetic processdefinition[GO:0045726]  
1
  • IMPBHF-UCL
Positive regulation of smooth muscle cell proliferationdefinition[GO:0048661]  
1
  • ISSBHF-UCL
Positive regulation vascular endothelial growth factor productiondefinition[GO:0010575]  
1
  • IEPBHF-UCL
Proton transportdefinition[GO:0015992]  
1
  • IDABHF-UCL
Regulation of blood pressuredefinition[GO:0008217]  
1
  • TASBHF-UCL
Regulation of systemic arterial blood pressure by renin-angiotensindefinition[GO:0003081] silver  
  • IEAOrtholog Compara
Respiratory burstdefinition[GO:0045730]  
1
  • TASBHF-UCL
Response to pHdefinition[GO:0009268]  
1
  • IDABHF-UCL
Signal transductiondefinition[GO:0007165]  
1
  • TASBHF-UCL
Superoxide anion generationdefinition[GO:0042554]  
1
  • IDABHF-UCL
Superoxide metabolic processdefinition[GO:0006801]  
1
  • IMPBHF-UCL
Transmembrane transportdefinition[GO:0055085]  
1
  • IDAGOC
Enzymatic activity 
It requires the following cofactors
NADP (Potential).  
  • CuratedUniProtKB
FAD (Potential).  
  • CuratedUniProtKB
It is regulated in the following manner
The oxidase activity is potentiated by NOXA1 and NOXO1.  
2
  • CuratedUniProtKB
 
More information is available from:
  • PeroxiBase: 5410 [ HsNOx01 ]
Pathways 
According to KEGG, this protein belongs to the following pathways:
Leukocyte transendothelial migration  hsa04670+27035  
Osteoclast differentiation  hsa04380+27035  
Phagosome  hsa04145+27035  
 

Keywords

Biological process 
Electron transport  definition   [KW-0249]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Oxidoreductase  definition   [KW-0560]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: NOX1
GenomeRNAi: 27035
PRO: PR:Q9Y5S8