RBM8A - RNA-binding protein 8A - human protein (Function)
 
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RBM8A »  RNA-binding protein 8A
 
Gene name:  RBM8A
Family name: RBM8A
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator WIBG/PYM leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Its removal from cytoplasmic mRNAs requires translation initiation from EJC-bearing spliced mRNAs. Associates preferentially with mRNAs produced by splicing. Does not interact with pre-mRNAs, introns, or mRNAs produced from intronless cDNAs. Associates with both nuclear mRNAs and newly exported cytoplasmic mRNAs. The MAGOH-RBM8A heterodimer is a component of the nonsense mediated decay (NMD) pathway. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC assembly.  
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  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the nuclear mrna exporter (mrna-e) family  3.A.18.1.1  
GO molecular function 
mRNA bindingdefinition[GO:0003729]  
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  • NASUniProtKB
Nucleotide bindingdefinition[GO:0000166] silver  
  • IEAInterPro 2 GO
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
15
  • IPIIntAct
  • IPIUniProtKB
RNA bindingdefinition[GO:0003723]  
1
  • NASUniProtKB
GO biological process 
mRNA splicing, via spliceosomedefinition[GO:0000398]  
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  • ICUniProtKB
Nuclear-transcribed mRNA catabolic process, nonsense-mediated decaydefinition[GO:0000184]  
1
  • IMPUniProtKB
Regulation of alternative mRNA splicing, via spliceosomedefinition[GO:0000381]  
1
  • IMPUniProtKB
Regulation of translationdefinition[GO:0006417]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
mRNA surveillance pathway  hsa03015+9939  
RNA transport  hsa03013+9939  
Spliceosome  hsa03040+9939  
According to Reactome, this protein belongs to the following pathways:
mRNA 3'-end processing  REACT_1849  
mRNA Splicing - Major Pathway  REACT_467  
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)  REACT_75822  
Transport of Mature mRNA derived from an Intron-Containing Transcript  REACT_1597  
 

Keywords

Biological process 
Nonsense-mediated mRNA decay  definition   [KW-0866]
Translation regulation  definition   [KW-0810]
Transport  definition   [KW-0813]
mRNA processing  definition   [KW-0507]
mRNA splicing  definition   [KW-0508]
mRNA transport  definition   [KW-0509]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: RBM8A
GenomeRNAi: 9939
PRO: PR:Q9Y5S9