KLF2 - Krueppel-like factor 2 - human protein (Function)
 
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KLF2 »  Krueppel-like factor 2
 
Protein also known as:  Lung krueppel-like factor.
Gene name:  KLF2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Binds to the CACCC box in the beta-globin gene promoter and activates transcription (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IEAOrtholog Compara
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAOrtholog Compara
GO biological process 
Cell morphogenesisdefinition[GO:0000902] silver  
  • IEAOrtholog Compara
Cellular response to cycloheximidedefinition[GO:0071409] silver  
  • IEAOrtholog Compara
Cellular response to hydrogen peroxidedefinition[GO:0070301] silver  
  • IEAOrtholog Compara
Cellular response to interleukin-1definition[GO:0071347] silver  
  • IEAOrtholog Compara
Cellular response to laminar fluid shear stressdefinition[GO:0071499]  
1
  • IMPBHF-UCL
Cellular response to peptidedefinition[GO:1901653] silver  
  • IEAOrtholog Compara
Cellular response to tumor necrosis factordefinition[GO:0071356] silver  
  • IEAOrtholog Compara
Erythrocyte maturationdefinition[GO:0043249] silver  
  • IEAOrtholog Compara
In utero embryonic developmentdefinition[GO:0001701] silver  
  • IEAOrtholog Compara
Multicellular organism growthdefinition[GO:0035264] silver  
  • IEAOrtholog Compara
Negative regulation of interleukin-6 productiondefinition[GO:0032715] silver  
  • IEAOrtholog Compara
Positive regulation of protein metabolic processdefinition[GO:0051247]  
1
  • IGIBHF-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IGIBHF-UCL
Positive regulation of transcription from RNA polymerase II promoter in response to stressdefinition[GO:0036003]  
1
  • IMPBHF-UCL
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Type I pneumocyte differentiationdefinition[GO:0060509] silver  
  • IEAOrtholog Compara
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: KLF2
GenomeRNAi: 10365
PRO: PR:Q9Y5W3