NR2E3 - Photoreceptor-specific nuclear receptor - human protein (Function)
 
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NR2E3 »  Photoreceptor-specific nuclear receptor
 
Protein also known as:  Nuclear receptor subfamily 2 group E member 3.
Gene name:  NR2E3
Family name: Nuclear hormone receptor » NR2
Entry whose protein(s) existence is based on evidence at protein level
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1 20 2
GENE REF ISO

Function

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Overview 
Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression.  
3
  • UniProtKB
GO molecular function 
Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activitydefinition[GO:0004879]  
1
  • PINC
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
1
  • InterPro 2 GO
Steroid hormone receptor activitydefinition[GO:0003707] silver  
1
  • InterPro 2 GO
Zinc ion bindingdefinition[GO:0008270] silver  
1
  • InterPro 2 GO
GO biological process 
Eye photoreceptor cell developmentdefinition[GO:0042462] silver  
1
  • Ortholog Compara
Intracellular receptor signaling pathwaydefinition[GO:0030522]  
1
  • GOC
Negative regulation of cell proliferationdefinition[GO:0008285] silver  
1
  • Ortholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
1
  • Ortholog Compara
Phototransductiondefinition[GO:0007602]  
1
  • PINC
Positive regulation of rhodopsin gene expressiondefinition[GO:0045872] silver  
1
  • Ortholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
1
  • Ortholog Compara
Retina development in camera-type eyedefinition[GO:0060041] silver  
1
  • Ortholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • PINC
Steroid hormone mediated signaling pathwaydefinition[GO:0043401] silver  
1
  • InterPro 2 GO
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • PINC
Visual perceptiondefinition[GO:0007601]  
1
  • UniProtKB KW
Pathways 
According to Reactome, this protein belongs to the following pathway:
Nuclear Receptor transcription pathway  REACT_15525  
 

Keywords

Biological process 
Sensory transduction  definition   [KW-0716]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Vision  definition   [KW-0844]
Molecular function 
Receptor  definition   [KW-0675]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links