NR2E3 - Photoreceptor-specific nuclear receptor - human protein (Sequence)
 
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NR2E3 »  Photoreceptor-specific nuclear receptor
 
Protein also known as:  Nuclear receptor subfamily 2 group E member 3.
Gene name:  NR2E3
Family name: Nuclear hormone receptor » NR2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 21 2
GENE REF ISO

Displayed isoform: Long     

 
 
Isoform Long   410 aaMass: 44692 Da,  pI: 8.17
METRPTALMS STVAAAAPAA GAASRKESPG RWGLGEDPTG VSPSLQCRVC GDSSSGKHYG IYACNGCSGF FKRSVRRRLI YRCQVGAGMC PVDKAHRNQC QACRLKKCLQ AGMNQDAVQN ERQPRSTAQV HLDSMESNTE SRPESLVAPP APAGRSPRGP TPMSAARALG HHFMASLITA ETCAKLEPED ADENIDVTSN DPEFPSSPYS SSSPCGLDSI HETSARLLFM AVKWAKNLPV FSSLPFRDQV ILLEEAWSEL FLLGAIQWSL PLDSCPLLAP PEASAAGGAQ GRLTLASMET RVLQETISRF RALAVDPTEF ACMKALVLFK PETRGLKDPE HVEALQDQSQ VMLSQHSKAH HPSQPVRFGK LLLLLPSLRF ITAERIELLF FRKTIGNTPM EKLLCDMFKN

Sequence

 show evidences
PTM 
Di- and tri-sumoylated in developing retina. PIAS3-mediated sumoylation promotes repression of cone-specific gene expression and activation of rod-specific genes. Sumoylation on Lys-185 appears to be the main site (By similarity).  
  • CuratedUniProtKB
 

Keywords

Coding sequence diversity 
Alternative splicing  definition   [KW-0025]
Polymorphism  definition   [KW-0621]
Domain 
Zinc-finger  definition   [KW-0863]
PTM 
Isopeptide bond  definition   [KW-1017]
Phosphoprotein  definition   [KW-0597]
Ubl conjugation  definition   [KW-0832]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Family and domain databases
Gene3D: 1.10.565.10
Gene3D: 3.30.50.10
InterPro: IPR001723 [ Str hrmn rcpt ]
InterPro: IPR001628 [ Znf hrmn rcpt ]
InterPro: IPR000003 [ Retinoid-X rcpt/HNF4 ]
InterPro: IPR000536 [ Nucl hrmn rcpt lig-bd core ]
InterPro: IPR013088 [ Znf NHR/GATA ]
InterPro: IPR008946 [ Nucl hormone rcpt ligand-bd ]
Pfam: PF00105 [ zf-C4 ]
Pfam: PF00104 [ Hormone recep ]
PRINTS: PR00047 [ STROIDFINGER ]
PRINTS: PR00398 [ STRDHORMONER ]
PRINTS: PR00545 [ RETINOIDXR ]
PROSITE: PS51030 [ NUCLEAR REC DBD 2 ]
PROSITE: PS00031 [ NUCLEAR REC DBD 1 ]
SMART: SM00430 [ HOLI ]
SMART: SM00399 [ ZnF C4 ]
SUPFAM: SSF48508 [ SSF48508 ]
Genome annotation databases
KEGG: hsa:10002
UCSC: uc002ath.1
Organism-specific databases
MGI: MGI:1346317 [ Nr2e3 ]
PTM databases
PhosphoSite: Q9Y5X4
Phylogenomic databases
eggNOG: NOG277339
HOGENOM: HOG000260820
HOVERGEN: HBG005606
InParanoid: Q9Y5X4
KO: K08546
PhylomeDB: Q9Y5X4
Sequence databases
EMBL: Genomic DNA:  AJ276674 . Translation:  CAB82769.1 .
EMBL: mRNA:  AB307710 . Translation:  BAH02301.1 .
EMBL: mRNA:  AF121129 . Translation:  AAD28301.1 .
EMBL: mRNA:  AF148128 . Translation:  AAF22227.1 .
EMBL: Genomic DNA:  CH471082 . Translation:  EAW77876.1 .
IPI: IPI00215922
IPI: IPI00001888
RefSeq: Protein:  NP_057430.1. Nucleotide sequence:  NM_016346.3.
RefSeq: Protein:  NP_055064.1. Nucleotide sequence:  NM_014249.3.
UniProtKB: Q9Y5X4 [ NR2E3 ]
Protocols and materials databases
DNASU: 10002