FLVCR1 - Feline leukemia virus subgroup C receptor-related protein 1 - human protein (Function)
 
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FLVCR1 »  Feline leukemia virus subgroup C receptor-related protein 1  (Feline leukemia virus subgroup C receptor)
 
Gene name:  FLVCR1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 42 2
GENE REF ISO

Function

 show evidences
Overview 
Isoform  Iso 1   Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export depends on the presence of HPX and may be required to protect developing erythroid cells from heme toxicity. Heme export also provides protection from heme or ferrous iron toxicities in liver and brain. Causes susceptibility to FeLV-C in vitro. Required during erythtopoiesis to maintain intracellular free heme balance since in proerythroblasts, heme synthesis intensifies and it's accumulation is toxic for cells.  
1
  • UniProtKB
Isoform  Iso 2   Heme transporter that promotes heme efflux from the mitochondrion to the cytoplasm. Essential for erythroid differentiation.  
1
  • UniProtKB
According to TCDB this is a transporter from family:
the major facilitator superfamily (mfs)  2.A.1.28.1  
GO molecular function 
Heme transporter activitydefinition[GO:0015232]  
2
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • UniProtKB
Transporter activitydefinition[GO:0005215]  
1
  • PINC
GO biological process 
Blood vessel developmentdefinition[GO:0001568] silver  
1
  • Ortholog Compara
Embryonic digit morphogenesisdefinition[GO:0042733] silver  
1
  • Ortholog Compara
Embryonic skeletal system morphogenesisdefinition[GO:0048704] silver  
1
  • Ortholog Compara
Erythrocyte differentiationdefinition[GO:0030218]  
1
  • MGI
Erythrocyte maturationdefinition[GO:0043249]  
1
  • UniProtKB KW
Head morphogenesisdefinition[GO:0060323] silver  
1
  • Ortholog Compara
Heme exportdefinition[GO:0097037]  
1
  • UniProtKB
Heme transportdefinition[GO:0015886]  
1
  • MGI
In utero embryonic developmentdefinition[GO:0001701] silver  
1
  • Ortholog Compara
Mitochondrial transportdefinition[GO:0006839]  
1
  • MGI
Multicellular organism growthdefinition[GO:0035264] silver  
1
  • Ortholog Compara
Multicellular organismal developmentdefinition[GO:0007275]  
1
  • PINC
Regulation of organ growthdefinition[GO:0046620] silver  
1
  • Ortholog Compara
Spleen developmentdefinition[GO:0048536] silver  
1
  • Ortholog Compara
Transportdefinition[GO:0006810]  
1
  • PINC
Pathways 
According to Reactome, this protein belongs to the following pathway:
Iron uptake and transport  R-HSA-917937  
 

Keywords

Biological process 
Erythrocyte maturation  definition   [KW-0265]
Transport  definition   [KW-0813]
Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FLVCR1
GenomeRNAi: 28982
PRO: PR:Q9Y5Y0