SCN10A - Sodium channel protein type 10 subunit alpha - human protein (Function)
 
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Protein
Gene
References

 
SCN10A »  Sodium channel protein type 10 subunit alpha
 
Protein also known as:  Voltage-gated sodium channel subunit alpha Nav1.8.
Gene name:  SCN10A
Entry whose protein(s) existence is based on evidence at protein level
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1 66 1
GENE REF ISO

Function

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Overview 
Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms.  
2
  • UniProtKB
GO molecular function 
Ion channel bindingdefinition[GO:0044325]  
1
  • BHF-UCL
Voltage-gated sodium channel activitydefinition[GO:0005248]  
1
  • BHF-UCL
GO biological process 
AV node cell action potentialdefinition[GO:0086016]  
1
  • BHF-UCL
Bundle of His cell action potentialdefinition[GO:0086043]  
1
  • BHF-UCL
Membrane depolarization during action potentialdefinition[GO:0086010]  
1
  • RefGenome
Neuronal action potentialdefinition[GO:0019228]  
1
  • RefGenome
Regulation of atrial cardiac muscle cell membrane depolarizationdefinition[GO:0060371]  
2
  • BHF-UCL
Regulation of cardiac muscle contractiondefinition[GO:0055117]  
1
  • BHF-UCL
Regulation of heart ratedefinition[GO:0002027]  
2
  • BHF-UCL
Regulation of ion transmembrane transportdefinition[GO:0034765]  
1
  • BHF-UCL
Sensory perceptiondefinition[GO:0007600]  
1
  • PINC
Sensory perception of paindefinition[GO:0019233] silver  
1
  • InterPro 2 GO
Sodium ion transmembrane transportdefinition[GO:0035725]  
1
  • BHF-UCL
Pathways 
According to Reactome, this protein belongs to the following pathway:
Interaction between L1 and Ankyrins  REACT_22266  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Sodium transport  definition   [KW-0739]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Sodium channel  definition   [KW-0894]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: SCN10A
GenomeRNAi: 6336
PRO: PR:Q9Y5Y9
Chemistry
GuidetoPHARMACOLOGY: 585