SCN10A - Sodium channel protein type 10 subunit alpha - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
SCN10A »  Sodium channel protein type 10 subunit alpha
 
Protein also known as:  Voltage-gated sodium channel subunit alpha Nav1.8.
Gene name:  SCN10A
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 47 1
GENE REF ISO

Function

 show evidences
Overview 
Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms.  
1
  • CuratedUniProtKB
GO molecular function 
Voltage-gated sodium channel activitydefinition[GO:0005248]  
1
  • IDABHF-UCL
GO biological process 
AV node cell to bundle of His cell communicationdefinition[GO:0086067]  
1
  • IMPBHF-UCL
Bundle of His cell to Purkinje myocyte communicationdefinition[GO:0086069]  
1
  • IMPBHF-UCL
Regulation of atrial cardiac muscle cell membrane depolarizationdefinition[GO:0060371]  
2
  • IMPBHF-UCL
Regulation of cardiac muscle contractiondefinition[GO:0055117]  
1
  • IMPBHF-UCL
Regulation of heart ratedefinition[GO:0002027]  
2
  • IMPBHF-UCL
Regulation of ion transmembrane transportdefinition[GO:0034765]  
1
  • IDABHF-UCL
Sensory perceptiondefinition[GO:0007600]  
1
  • TASPINC
Sodium ion transmembrane transportdefinition[GO:0035725]  
1
  • IDABHF-UCL
Sodium ion transportdefinition[GO:0006814]  
1
  • TASPINC
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Sodium transport  definition   [KW-0739]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Sodium channel  definition   [KW-0894]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: SCN10A
GenomeRNAi: 6336
PRO: PR:Q9Y5Y9
Chemistry
GuidetoPHARMACOLOGY: 585