BACE2 - Beta-secretase 2 - human protein (Function)
 
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BACE2 »  Beta-secretase 2   [ EC 3.4.23.45 ]
 
Protein also known as:  Beta-site amyloid precursor protein cleaving enzyme 2 (Beta-site APP cleaving enzyme 2).
Gene name:  BACE2
Family name: Peptidase A1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.  
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  • CuratedUniProtKB
GO molecular function 
Aspartic-type endopeptidase activitydefinition[GO:0004190]  
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  • IDAUniProtKB
GO biological process 
Membrane protein ectodomain proteolysisdefinition[GO:0006509]  
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  • IDAUniProtKB
Negative regulation of amyloid precursor protein biosynthetic processdefinition[GO:0042985]  
1
  • IMPUniProtKB
Peptide hormone processingdefinition[GO:0016486]  
1
  • NASUniProtKB
Proteolysisdefinition[GO:0006508]  
1
  • NASUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.23.45: Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer amyloid precursor protein.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Alzheimer's disease  hsa05010+25825  
 
More information is available from:
 

Keywords

Molecular function 
Aspartyl protease  definition   [KW-0064]
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Beta-secretase_2
GenomeRNAi: 25825
PRO: PR:Q9Y5Z0
Chemistry
GuidetoPHARMACOLOGY: 2331