IRAK3 - Interleukin-1 receptor-associated kinase 3 - human protein (Function)
 
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IRAK3 »  Interleukin-1 receptor-associated kinase 3   [ EC 2.7.11.1 ]  (IRAK-3)
 
Protein also known as:  IL-1 receptor-associated kinase M (IRAK-M).
Gene name:  IRAK3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
Overview 
Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex (By similarity).  
1
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • IDAUniProtKB
Magnesium ion bindingdefinition[GO:0000287]  
1
  • IDAUniProtKB
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • IPIBHF-UCL
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IPIBHF-UCL
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • IDAUniProtKB
GO biological process 
Cytokine-mediated signaling pathwaydefinition[GO:0019221]  
  • ISSOrtholog Curator
Interleukin-1-mediated signaling pathwaydefinition[GO:0070498]  
1
  • IMPBHF-UCL
MyD88-dependent toll-like receptor signaling pathwaydefinition[GO:0002755]  
1
  • TASBHF-UCL
Negative regulation of cytokine-mediated signaling pathwaydefinition[GO:0001960]  
1
  • ICBHF-UCL
Negative regulation of innate immune responsedefinition[GO:0045824]  
1
  • ISSBHF-UCL
Negative regulation of interleukin-12 productiondefinition[GO:0032695]  
2
  • IMPBHF-UCL
Negative regulation of interleukin-6 productiondefinition[GO:0032715]  
2
  • IMPBHF-UCL
Negative regulation of macrophage cytokine productiondefinition[GO:0010936]  
1
  • ISSBHF-UCL
Negative regulation of MAP kinase activitydefinition[GO:0043407]  
1
  • IMPBHF-UCL
Negative regulation of NF-kappaB transcription factor activitydefinition[GO:0032088]  
2
  • IMPBHF-UCL
Negative regulation of protein catabolic processdefinition[GO:0042177]  
2
  • IMPBHF-UCL
Negative regulation of protein complex disassemblydefinition[GO:0043242]  
1
  • IMPBHF-UCL
Negative regulation of toll-like receptor signaling pathwaydefinition[GO:0034122]  
1
  • ISSBHF-UCL
Negative regulation of tumor necrosis factor productiondefinition[GO:0032720]  
1
  • IMPBHF-UCL
Positive regulation of macrophage tolerance inductiondefinition[GO:0010933]  
1
  • ISSBHF-UCL
Positive regulation of NF-kappaB transcription factor activitydefinition[GO:0051092]  
1
  • IMPBHF-UCL
Protein autophosphorylationdefinition[GO:0046777] silver  
  • IEAOrtholog Compara
Protein phosphorylationdefinition[GO:0006468]  
1
  • IDAUniProtKB
Regulation of protein complex disassemblydefinition[GO:0043244]  
  • ISSOrtholog Curator
Response to exogenous dsRNAdefinition[GO:0043330]  
1
  • ISSBHF-UCL
Response to interleukin-1definition[GO:0070555]  
1
  • IMPBHF-UCL
Response to lipopolysaccharidedefinition[GO:0032496]  
1
  • ISSBHF-UCL
Response to peptidoglycandefinition[GO:0032494]  
1
  • ISSBHF-UCL
Response to virusdefinition[GO:0009615]  
1
  • ICBHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
1
  • CuratedUniProtKB
It requires the following cofactor
Magnesium.  
1
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Apoptosis  hsa04210+11213  
Neurotrophin signaling pathway  hsa04722+11213  
According to Reactome, this protein belongs to the following pathways:
Interleukin-1 signaling  REACT_22442  
MyD88:Mal cascade initiated on plasma membrane  REACT_6788  
Caution 
Ser-293 is present instead of the conserved Asp which is expected to be an active site residue. Low level autophosphorylation activity has been reported in PubMed10383454, while other authors describe this as an inactive kinase.  
1
  • CuratedUniProtKB
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: IRAK3
GenomeRNAi: 11213
PRO: PR:Q9Y616
Chemistry
GuidetoPHARMACOLOGY: 2044