IRAK3 - Interleukin-1 receptor-associated kinase 3 - human protein (Function)
 
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IRAK3 »  Interleukin-1 receptor-associated kinase 3   [ EC 2.7.11.1 ]  (IRAK-3)
 
Protein also known as:  IL-1 receptor-associated kinase M (IRAK-M).
Gene name:  IRAK3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

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Overview 
Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.  
2
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB
Magnesium ion bindingdefinition[GO:0000287]  
1
  • UniProtKB
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • BHF-UCL
Protein homodimerization activitydefinition[GO:0042803]  
1
  • BHF-UCL
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • UniProtKB
GO biological process 
Cytokine-mediated signaling pathwaydefinition[GO:0019221]  
1
  • Ortholog Curator
Interleukin-1-mediated signaling pathwaydefinition[GO:0070498]  
1
  • BHF-UCL
MyD88-dependent toll-like receptor signaling pathwaydefinition[GO:0002755]  
1
  • BHF-UCL
Negative regulation of cytokine-mediated signaling pathwaydefinition[GO:0001960]  
1
  • BHF-UCL
Negative regulation of innate immune responsedefinition[GO:0045824]  
1
  • BHF-UCL
Negative regulation of interleukin-12 productiondefinition[GO:0032695]  
2
  • BHF-UCL
Negative regulation of interleukin-6 productiondefinition[GO:0032715]  
2
  • BHF-UCL
Negative regulation of macrophage cytokine productiondefinition[GO:0010936]  
1
  • BHF-UCL
Negative regulation of MAP kinase activitydefinition[GO:0043407]  
1
  • BHF-UCL
Negative regulation of NF-kappaB transcription factor activitydefinition[GO:0032088]  
2
  • BHF-UCL
Negative regulation of protein catabolic processdefinition[GO:0042177]  
2
  • BHF-UCL
Negative regulation of protein complex disassemblydefinition[GO:0043242]  
1
  • BHF-UCL
Negative regulation of toll-like receptor signaling pathwaydefinition[GO:0034122]  
1
  • BHF-UCL
Negative regulation of tumor necrosis factor productiondefinition[GO:0032720]  
1
  • BHF-UCL
Positive regulation of macrophage tolerance inductiondefinition[GO:0010933]  
1
  • BHF-UCL
Positive regulation of NF-kappaB transcription factor activitydefinition[GO:0051092]  
1
  • BHF-UCL
Protein autophosphorylationdefinition[GO:0046777] silver  
1
  • Ortholog Compara
Protein phosphorylationdefinition[GO:0006468]  
1
  • UniProtKB
Regulation of protein complex disassemblydefinition[GO:0043244]  
1
  • Ortholog Curator
Response to exogenous dsRNAdefinition[GO:0043330]  
1
  • BHF-UCL
Response to interleukin-1definition[GO:0070555]  
1
  • BHF-UCL
Response to lipopolysaccharidedefinition[GO:0032496]  
1
  • BHF-UCL
Response to peptidoglycandefinition[GO:0032494]  
1
  • BHF-UCL
Response to virusdefinition[GO:0009615]  
1
  • BHF-UCL
Toll-like receptor signaling pathwaydefinition[GO:0002224]  
1
  • RefGenome
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
2
  • UniProtKB
It requires the following cofactor
 Mg(2+)  
2
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Apoptosis  hsa04210+11213  
Neurotrophin signaling pathway  hsa04722+11213  
According to Reactome, this protein belongs to the following pathways:
Interleukin-1 signaling  REACT_22442  
MyD88:Mal cascade initiated on plasma membrane  REACT_6788  
Caution 
Ser-293 is present instead of the conserved Asp which is expected to be an active site residue. Low level autophosphorylation activity has been reported in PubMed:10383454, while other authors describe this as an inactive kinase.  
1
  • UniProtKB
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: IRAK3
GenomeRNAi: 11213
PRO: PR:Q9Y616
Chemistry
GuidetoPHARMACOLOGY: 2044