GPR56 - G-protein coupled receptor 56 - human protein (Function)
 
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GPR56 »  G-protein coupled receptor 56
 
Protein also known as:  Protein TM7XN1. Cleaved into:  GPR56 C-terminal fragment; GPR56 N-terminal fragment.
Gene name:  GPR56
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Involved in cell adhesion and probably in cell-cell interactions. Regulates the migration of neural precursor cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basemant membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Isoforms show differences in receptor signaling, specifically in serum response element (SRE) transcriptional activation upon overexpression. Overexpression inhibits melanoma tumor growth and metastasis and, during melanoma progression, regulates VEGFA production and angiogenesis through PRKCA; unprocessed GPR56 is inhibiting and GPR56 NT is activating angiogenesis. Required for normal cortical development and regulation of neuroprogenitor cells proliferation.  
6
  • UniProtKB
GO molecular function 
Collagen bindingdefinition[GO:0005518]  
1
  • Ortholog Curator
Extracellular matrix bindingdefinition[GO:0050840]  
1
  • Ortholog Curator
G-protein coupled receptor activitydefinition[GO:0004930]  
1
  • Ortholog Curator
GO biological process 
Angiogenesisdefinition[GO:0001525]  
1
  • UniProtKB
Brain developmentdefinition[GO:0007420]  
1
  • GDB
Cell adhesiondefinition[GO:0007155]  
1
  • UniProtKB KW
Cell-cell signalingdefinition[GO:0007267]  
1
  • PINC
Cerebral cortex radial glia guided migrationdefinition[GO:0021801]  
1
  • Ortholog Curator
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
2
  • GDB
  • PINC
Layer formation in cerebral cortexdefinition[GO:0021819]  
1
  • Ortholog Curator
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • UniProtKB
Negative regulation of neuron migrationdefinition[GO:2001223]  
1
  • Ortholog Curator
Neuropeptide signaling pathwaydefinition[GO:0007218] silver  
1
  • InterPro 2 GO
Positive regulation of cell adhesiondefinition[GO:0045785]  
1
  • UniProtKB
Positive regulation of Rho protein signal transductiondefinition[GO:0035025]  
1
  • Ortholog Curator
Protein kinase C signalingdefinition[GO:0070528]  
1
  • UniProtKB
Rho protein signal transductiondefinition[GO:0007266]  
1
  • UniProtKB
Vascular endothelial growth factor productiondefinition[GO:0010573]  
1
  • UniProtKB
Enzymatic activity 
It is regulated in the following manner
GPR56 NT is proposed to inhibit receptor signaling; its interactions with extracellular ligands and /or homophilic GPR56 NT interactions may relieve the inhibition.  
2
  • UniProtKB
 
More information is available from:
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Differentiation  definition   [KW-0221]
Neurogenesis  definition   [KW-0524]
Molecular function 
Developmental protein  definition   [KW-0217]
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 9289
PRO: PR:Q9Y653