SPIN1 - Spindlin-1 - human protein (Function)
 
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SPIN1 »  Spindlin-1
 
Protein also known as:  Ovarian cancer-related protein.
Gene name:  SPIN1
Family name: SPIN/STSY
Entry whose protein(s) existence is based on evidence at protein level
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1 34 1
GENE REF ISO

Function

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Overview 
Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway dowstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed21960006). May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption.  
4
  • UniProtKB
GO molecular function 
Methylated histone bindingdefinition[GO:0035064]  
4
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IntAct
  • UniProtKB
GO biological process 
Chromatin modificationdefinition[GO:0016568]  
1
  • UniProtKB KW
Gamete generationdefinition[GO:0007276] silver  
1
  • InterPro 2 GO
Meiotic cell cycledefinition[GO:0051321]  
1
  • UniProtKB KW
Multicellular organismal developmentdefinition[GO:0007275]  
1
  • UniProtKB KW
Positive regulation of Wnt signaling pathwaydefinition[GO:0030177]  
1
  • UniProtKB
rRNA transcriptiondefinition[GO:0009303]  
1
  • UniProtKB
Wnt signaling pathwaydefinition[GO:0016055]  
1
  • UniProtKB KW
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Meiosis  definition   [KW-0469]
Wnt signaling pathway  definition   [KW-0879]
Molecular function 
Chromatin regulator  definition   [KW-0156]
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SPIN1
GenomeRNAi: 10927
PRO: PR:Q9Y657