SLC12A7 - Solute carrier family 12 member 7 - human protein (Function)
 
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Protein
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SLC12A7 »  Solute carrier family 12 member 7
 
Protein also known as:  Electroneutral potassium-chloride cotransporter 4.
Gene name:  SLC12A7
Family name: SLC12A transporter
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 36 2
GENE REF ISO

Function

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Overview 
Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity).  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the cation-chloride cotransporter (ccc) family  2.A.30.5.4  
GO molecular function 
Potassium:chloride symporter activitydefinition[GO:0015379] silver  
  • IEAInterPro 2 GO
GO biological process 
Anion transportdefinition[GO:0006820]  
1
  • TASGOC
Cell volume homeostasisdefinition[GO:0006884] silver  
  • IEAOrtholog Compara
Chloride transmembrane transportdefinition[GO:1902476]  
1
  • TASGOC
Chloride transportdefinition[GO:0006821]  
1
  • TASGOC
Inorganic anion transportdefinition[GO:0015698]  
1
  • TASGOC
Ion transmembrane transportdefinition[GO:0034220]  
1
  • TASGOC
Potassium ion transportdefinition[GO:0006813]  
  • IEAUniProtKB KW
Transportdefinition[GO:0006810]  
1
  • TASPINC
Enzymatic activity 
It is regulated in the following manner
Activated by N-ethylmaleimide (NEM). Inhibited by furosemide, DIDS and bumetanide. The inhibition is much stronger in the presence of 50 mM K(+) in the uptake medium. Inhibited by DIOA. Inhibited by WNK3.  
1
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Collecting duct acid secretion  hsa04966+10723  
According to Reactome, this protein belongs to the following pathway:
Transmembrane transport of small molecules  REACT_15518  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Symport  definition   [KW-0769]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: SLC12A7
GenomeRNAi: 10723
PRO: PR:Q9Y666
Chemistry
GuidetoPHARMACOLOGY: 974