KCNMB2 - Calcium-activated potassium channel subunit beta-2 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
KCNMB2 »  Calcium-activated potassium channel subunit beta-2
 
Protein also known as:  Calcium-activated potassium channel, subfamily M subunit beta-2.
Gene name:  KCNMB2
Family name: KCNMB (TC 8.A.14.1) » KCNMB2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 24 1
GENE REF ISO

Function

 show evidences
Overview 
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons.  
3
  • UniProtKB
According to TCDB this is a transporter from family:
the ca(2+)-activated k(+) channel auxiliary subunit slowpoke- (slo) family  8.A.14.1.3  
GO molecular function 
Calcium-activated potassium channel activitydefinition[GO:0015269]  
1
  • UniProtKB
Ion channel inhibitor activitydefinition[GO:0008200]  
1
  • PINC
Potassium channel regulator activitydefinition[GO:0015459]  
1
  • PINC
GO biological process 
Action potentialdefinition[GO:0001508]  
1
  • UniProtKB
Detection of calcium iondefinition[GO:0005513]  
1
  • UniProtKB
Neuronal action potentialdefinition[GO:0019228]  
1
  • UniProtKB
Potassium ion transmembrane transportdefinition[GO:0071805]  
2
  • GOC
  • InterPro 2 GO
Potassium ion transportdefinition[GO:0006813]  
1
  • UniProtKB
Regulation of vasoconstrictiondefinition[GO:0019229]  
1
  • UniProtKB
Synaptic transmissiondefinition[GO:0007268]  
1
  • RefGenome
Pathways 
According to KEGG, this protein belongs to the following pathway:
Vascular smooth muscle contraction  hsa04270+10242  
According to Reactome, this protein belongs to the following pathways:
Ca2+ activated K+ channels  REACT_75896  
cGMP effects  REACT_23767  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: KCNMB2
GenomeRNAi: 10242
PRO: PR:Q9Y691