KCNMB2 - Calcium-activated potassium channel subunit beta-2 - human protein (Function)
 
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KCNMB2 »  Calcium-activated potassium channel subunit beta-2
 
Protein also known as:  Calcium-activated potassium channel, subfamily M subunit beta-2.
Gene name:  KCNMB2
Family name: KCNMB (TC 8.A.14.1) » KCNMB2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

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Overview 
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons.  
2
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the ca(2+)-activated k(+) channel auxiliary subunit slowpoke- (slo) family  8.A.14.1.3  
GO molecular function 
Calcium-activated potassium channel activitydefinition[GO:0015269]  
1
  • IDAUniProtKB
Ion channel inhibitor activitydefinition[GO:0008200]  
1
  • TASPINC
Potassium channel regulator activitydefinition[GO:0015459]  
1
  • TASPINC
GO biological process 
Action potentialdefinition[GO:0001508]  
1
  • IDAUniProtKB
Detection of calcium iondefinition[GO:0005513]  
1
  • IDAUniProtKB
Ion transmembrane transportdefinition[GO:0034220]  
1
  • IDAGOC
Neuronal action potentialdefinition[GO:0019228]  
1
  • IDAUniProtKB
Potassium ion transmembrane transportdefinition[GO:0071805]  
1
  • IDAGOC
Potassium ion transportdefinition[GO:0006813]  
1
  • IDAUniProtKB
Regulation of vasoconstrictiondefinition[GO:0019229]  
1
  • TASUniProtKB
Transmembrane transportdefinition[GO:0055085]  
1
  • IDAGOC
Pathways 
According to KEGG, this protein belongs to the following pathway:
Vascular smooth muscle contraction  hsa04270+10242  
According to Reactome, this protein belongs to the following pathways:
Hemostasis  REACT_604  
Neuronal System  REACT_13685  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: KCNMB2
GenomeRNAi: 10242
PRO: PR:Q9Y691