CACNG2 - Voltage-dependent calcium channel gamma-2 subunit - human protein (Function)
 
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CACNG2 »  Voltage-dependent calcium channel gamma-2 subunit
 
Protein also known as:  Neuronal voltage-gated calcium channel gamma-2 subunit.
Gene name:  CACNG2
Family name: PMP-22/EMP/MP20 » CACNG
Entry whose protein(s) existence is based on evidence at protein level
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1 24 1
GENE REF ISO

Function

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Overview 
Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the ca(+) channel auxiliary subunit 1-8 (cca) family  8.A.16.2.1  
GO molecular function 
Ionotropic glutamate receptor bindingdefinition[GO:0035255] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Voltage-gated calcium channel activitydefinition[GO:0005245] silver  
  • IEAOrtholog Compara
GO biological process 
Membrane hyperpolarizationdefinition[GO:0060081] silver  
  • IEAOrtholog Compara
Neuromuscular junction developmentdefinition[GO:0007528] silver  
  • IEAOrtholog Compara
Regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activitydefinition[GO:2000311]  
  • ISSOrtholog Curator
Transmission of nerve impulsedefinition[GO:0019226] silver  
  • IEAOrtholog Compara
Transportdefinition[GO:0006810]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Arrhythmogenic right ventricular cardiomyopathy (ARVC)  hsa05412+10369  
Cardiac muscle contraction  hsa04260+10369  
Dilated cardiomyopathy  hsa05414+10369  
Hypertrophic cardiomyopathy (HCM)  hsa05410+10369  
MAPK signaling pathway  hsa04010+10369  
According to Reactome, this protein belongs to the following pathway:
Neuronal System  REACT_13685  
 

Keywords

Biological process 
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Calcium channel  definition   [KW-0107]
Ion channel  definition   [KW-0407]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CACNG2
GenomeRNAi: 10369
PRO: PR:Q9Y698