POMT1 - Protein O-mannosyl-transferase 1 - human protein (Function)
 
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POMT1 »  Protein O-mannosyl-transferase 1   [ EC 2.4.1.109 ]
 
Protein also known as:  Dolichyl-phosphate-mannose--protein mannosyltransferase 1.
Gene name:  POMT1
Family name: Glycosyltransferase 39
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient.  
3
  • UniProtKB
GO molecular function 
Dolichyl-phosphate-mannose-protein mannosyltransferase activitydefinition[GO:0004169]  
1
  • EC 2 GO
Mannosyltransferase activitydefinition[GO:0000030]  
1
  • PINC
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
GO biological process 
Carbohydrate metabolic processdefinition[GO:0005975]  
1
  • PINC
Extracellular matrix organizationdefinition[GO:0030198] silver  
1
  • Ortholog Compara
Mannosylationdefinition[GO:0097502]  
1
  • GOC
Multicellular organismal developmentdefinition[GO:0007275]  
1
  • PINC
Protein O-linked glycosylationdefinition[GO:0006493]  
1
  • PINC
Protein O-linked mannosylationdefinition[GO:0035269]  
1
  • EC 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.4.1.109: Dolichyl D-mannosyl phosphate + protein dolichyl phosphate + O-D-mannosylprotein.  
2
  • UniProtKB
It is regulated in the following manner
Slightly activated by Mg(2+) and inhibited by both Ca(+) and Mn(2+). EDTA ha no effect on activity in vitro.  
2
  • UniProtKB
According to CAZy, this protein is belongs to the following pathway:
Glycosyltransferase Family 39  GT39  
 
More information is available from:
Pathways 
This protein is involved in the following pathway
Protein modification; protein glycosylation  
1
  • UniProtKB
According to KEGG, this protein belongs to the following pathway:
Other types of O-glycan biosynthesis  hsa00514+10585  
 

Keywords

Molecular function 
Glycosyltransferase  definition   [KW-0328]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: POMT1
GenomeRNAi: 10585
PRO: PR:Q9Y6A1