CYP46A1 - Cholesterol 24-hydroxylase - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
CYP46A1 »  Cholesterol 24-hydroxylase   [ EC 1.14.13.98 ]  (CH24H)
 
Protein also known as:  Cytochrome P450 46A1.
Gene name:  CYP46A1
Family name: Cytochrome P450
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 45 3
GENE REF ISO

Function

 show evidences
Overview 
Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol. Has also activity with xenobiotic compounds, such as clotrimazole.  
2
  • CuratedUniProtKB
GO molecular function 
Cholesterol 24-hydroxylase activitydefinition[GO:0033781]  
1
  • IDAUniProtKB
Heme bindingdefinition[GO:0020037]  
1
  • IDAUniProtKB
Iron ion bindingdefinition[GO:0005506] silver  
  • IEAInterPro 2 GO
Steroid hydroxylase activitydefinition[GO:0008395]  
1
  • TASPINC
GO biological process 
Cholesterol catabolic processdefinition[GO:0006707]  
1
  • IDAUniProtKB
Nervous system developmentdefinition[GO:0007399]  
1
  • TASPINC
Oxidation-reduction processdefinition[GO:0055114]  
  • IEAUniProtKB KW
Xenobiotic metabolic processdefinition[GO:0006805]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.14.13.98: Cholesterol + NADPH + O(2) (24S)-24-hydroxycholesterol + NADP(+) + H(2)O.  
1
  • CuratedUniProtKB
It requires the following cofactor
Heme group.  
3
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Primary bile acid biosynthesis  hsa00120+10858  
According to Reactome, this protein belongs to the following pathways:
Endogenous sterols  REACT_13812  
Synthesis of bile acids and bile salts via 24-hydroxycholesterol  REACT_11053  
 

Biophysicochemical properties

Kinetic parameters
KM 2.2 uM for 24(S)-hydroxycholesterol

Keywords

Biological process 
Cholesterol metabolism  definition   [KW-0153]
Lipid metabolism  definition   [KW-0443]
Steroid metabolism  definition   [KW-0753]
Sterol metabolism  definition   [KW-1207]
Molecular function 
Monooxygenase  definition   [KW-0503]
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q9Y6A2
Other
GeneWiki: CYP46A1
GenomeRNAi: 10858
PRO: PR:Q9Y6A2