PTCH2 - Protein patched homolog 2 - human protein (Function)
 
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PTCH2 »  Protein patched homolog 2  (PTC2)
 
Gene name:  PTCH2
Family name: Patched
Entry whose protein(s) existence is based on evidence at transcript level
extend overview
1 28 2
GENE REF ISO

Function

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Overview 
May have a role in epidermal development. May act as a receptor for Sonic hedgehog (SHH).  
  • CuratedUniProtKB
GO molecular function 
Hedgehog family protein bindingdefinition[GO:0097108]  
2
  • TASBHF-UCL
Hedgehog receptor activitydefinition[GO:0008158]  
1
  • TASBHF-UCL
Smoothened bindingdefinition[GO:0005119]  
1
  • IPIBHF-UCL
GO biological process 
Epidermis developmentdefinition[GO:0008544] silver  
  • IEAOrtholog Compara
Hair cycledefinition[GO:0042633] silver  
  • IEAOrtholog Compara
Negative regulation of smoothened signaling pathwaydefinition[GO:0045879]  
1
  • TASBHF-UCL
Signal transductiondefinition[GO:0007165]  
1
  • TASGOC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Basal cell carcinoma  hsa05217+8643  
Hedgehog signaling pathway  hsa04340+8643  
Pathways in cancer  hsa05200+8643  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 8643
PRO: PR:Q9Y6C5