ARFGEF2 - Brefeldin A-inhibited guanine nucleotide-exchange protein 2 - human protein (Function)
 
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ARFGEF2 »  Brefeldin A-inhibited guanine nucleotide-exchange protein 2  (Brefeldin A-inhibited GEP 2)
 
Protein also known as:  ADP-ribosylation factor guanine nucleotide-exchange factor 2.
Gene name:  ARFGEF2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extend on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways.  
7
  • CuratedUniProtKB
GO molecular function 
ARF guanyl-nucleotide exchange factor activitydefinition[GO:0005086]  
1
  • IDAUniProtKB
  • IBARefGenome
GABA receptor bindingdefinition[GO:0050811]  
  • ISSOrtholog Curator
Guanyl-nucleotide exchange factor activitydefinition[GO:0005085]  
1
  • IDAMGI
Myosin bindingdefinition[GO:0017022] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
Protein kinase A regulatory subunit bindingdefinition[GO:0034237]  
1
  • IDAUniProtKB
GO biological process 
Endomembrane system organizationdefinition[GO:0010256]  
1
  • IMPUniProtKB
Endosome organizationdefinition[GO:0007032]  
1
  • IMPUniProtKB
Exocytosisdefinition[GO:0006887] silver  
  • IEAOrtholog Compara
Golgi to plasma membrane transportdefinition[GO:0006893]  
1
  • IMPUniProtKB
Intracellular signal transductiondefinition[GO:0035556]  
1
  • IDAMGI
Positive regulation of GTPase activitydefinition[GO:0043547]  
2
  • IDAGOC
  • IEAUniProtKB KW
  • IEAInterPro 2 GO
  • IBARefGenome
Positive regulation of tumor necrosis factor productiondefinition[GO:0032760]  
1
  • IMPUniProtKB
Protein transportdefinition[GO:0015031]  
  • IEAUniProtKB KW
Receptor recyclingdefinition[GO:0001881]  
1
  • IDAUniProtKB
Regulation of ARF protein signal transductiondefinition[GO:0032012] silver  
  • IEAInterPro 2 GO
Vesicle-mediated transportdefinition[GO:0016192] silver  
  • IBARefGenome
Enzymatic activity 
It is regulated in the following manner
Inhibited by brefeldin A.  
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Association of TriC/CCT with target proteins during biosynthesis  REACT_16907  
 

Keywords

Biological process 
Protein transport  definition   [KW-0653]
Transport  definition   [KW-0813]
Molecular function 
Guanine-nucleotide releasing factor  definition   [KW-0344]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ARFGEF2
GenomeRNAi: 10564
PRO: PR:Q9Y6D5