STK24 - Serine/threonine-protein kinase 24 - human protein (Function)
 
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References

 
STK24 »  Serine/threonine-protein kinase 24   [ EC 2.7.11.1 ]
 
Protein also known as:  Mammalian STE20-like protein kinase 3 (MST-3). Cleaved into:  Serine/threonine-protein kinase 24 12 kDa subunit; Serine/threonine-protein kinase 24 36 kDa subunit.
Gene name:  STK24
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 43 2
GENE REF ISO

Function

 show evidences
Overview 
Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve.  
5
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
5
  • IPIIntAct
Protein kinase activitydefinition[GO:0004672]  
1
  • TASPINC
Protein serine/threonine kinase activitydefinition[GO:0004674]  
2
  • IDAUniProtKB
Receptor signaling protein serine/threonine kinase activitydefinition[GO:0004702] silver  
  • IBARefGenome
GO biological process 
Execution phase of apoptosisdefinition[GO:0097194]  
1
  • IMPUniProtKB
Intrinsic apoptotic signaling pathway in response to oxidative stressdefinition[GO:0008631]  
1
  • IMPUniProtKB
Negative regulation of cell migrationdefinition[GO:0030336]  
1
  • IMPUniProtKB
Protein autophosphorylationdefinition[GO:0046777]  
1
  • IDAUniProtKB
Protein phosphorylationdefinition[GO:0006468]  
1
  • IDAUniProtKB
Regulation of axon regenerationdefinition[GO:0048679]  
1
  • IMPUniProtKB
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Signal transduction by phosphorylationdefinition[GO:0023014] silver  
  • IBARefGenome
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It requires the following cofactor
Mg(2+) or Mn(2+) or Co(2+) or Zn(2+).  
1
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Apoptosis  REACT_578  
 

Biophysicochemical properties

Kinetic parameters
KM 22.7 uM for magnesium ions
KM 4.1 uM for zinc ions
KM 12.8 uM for manganese ions
KM 34.9 uM for cobalt ions
Vmax 129.1 pmol/min/mg enzyme for magnesium ions
Vmax 22.3 pmol/min/mg enzyme for zinc ions
Vmax 2623.1 pmol/min/mg enzyme for manganese ions
Vmax 1746.1 pmol/min/mg enzyme for cobalt ions

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: STK24
GenomeRNAi: 8428
PRO: PR:Q9Y6E0
Chemistry
GuidetoPHARMACOLOGY: 2217