SNCAIP - Synphilin-1 - human protein (Function)
 
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Protein
Gene
References

 
SNCAIP »  Synphilin-1  (Sph1)
 
Protein also known as:  Alpha-synuclein-interacting protein.
Gene name:  SNCAIP
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 63 6
GENE REF ISO

Function

 show evidences
Overview 
Isoform  Iso 2   Modulates SNCA monoubiquitination by SIAH1.  
2
  • CuratedUniProtKB
Isoform  Iso 2   Inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins.  
2
  • CuratedUniProtKB
Isoform  Iso 2   Inhibits autoubiquitination and proteasomal degradation of SIAH1, and thereby increases cellular levels of SIAH.  
2
  • CuratedUniProtKB
GO molecular function 
Identical protein bindingdefinition[GO:0042802]  
1
  • IPIIntAct
Protein bindingdefinition[GO:0005515]  
7
  • IPIIntAct
  • IPIUniProtKB
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
1
  • IPIUniProtKB
GO biological process 
Cell deathdefinition[GO:0008219]  
  • IEAUniProtKB KW
Dopamine metabolic processdefinition[GO:0042417]  
1
  • IDAMGI
Regulation of inclusion body assemblydefinition[GO:0090083]  
1
  • IDABHF-UCL
Regulation of neurotransmitter secretiondefinition[GO:0046928]  
1
  • IDAMGI
Pathways 
According to KEGG, this protein belongs to the following pathway:
Parkinson's disease  hsa05012+9627  
Note 
Constructs encoding portions of SNCA and SNCAIP co-transfected in mammalian cells promote cytosolic inclusions resembling the Lewy bodies of Parkinson disease. Coexpression of SNCA, SNCAIP, and PARK2 result in the formation of Lewy body-like. Ubiquitin-positive cytosolic inclusions. SNCAIP isoform 2 is particularly aggregation-prone. Familial mutations in PARK2 disrupt the ubiquitination of SNCAIP and the formation of the ubiquitin-positive inclusions. These results provide a molecular basis for the ubiquitination of Lewy body-associated proteins and link PARK2 and SNCA in a common pathogenic mechanism through their interaction with SNCAIP.  
  • CuratedUniProtKB
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SNCAIP
GenomeRNAi: 9627
PRO: PR:Q9Y6H5