CABIN1 - Calcineurin-binding protein cabin-1 - human protein (Function)
 
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CABIN1 »  Calcineurin-binding protein cabin-1
 
Protein also known as:  Calcineurin inhibitor (CAIN).
Gene name:  CABIN1
Entry whose protein(s) existence is based on evidence at protein level
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1 48 2
GENE REF ISO

Function

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Overview 
May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes.  
2
  • CuratedUniProtKB
GO molecular function 
Protein phosphatase inhibitor activitydefinition[GO:0004864]  
1
  • NASUniProtKB
GO biological process 
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • NASUniProtKB
Chromatin modificationdefinition[GO:0016568]  
  • IEAUniProtKB KW
DNA replication-independent nucleosome assemblydefinition[GO:0006336]  
1
  • IDAUniProtKB
Negative regulation of catalytic activitydefinition[GO:0043086]  
1
  • NASGOC
Pathways 
According to Reactome, this protein belongs to the following pathway:
Formation of Senescence-Associated Heterochromatin Foci (SAHF)  REACT_169121  
 

Keywords

Molecular function 
Chromatin regulator  definition   [KW-0156]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CABIN1
GenomeRNAi: 23523
PRO: PR:Q9Y6J0