AK5 - Adenylate kinase isoenzyme 5 - human protein (Function)
 
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AK5 »  Adenylate kinase isoenzyme 5   [ EC 2.7.4.6EC 2.7.4.3 ]  (AK 5)
 
Protein also known as:  ATP-AMP transphosphorylase 5.
Gene name:  AK5
Family name: Adenylate kinase
Entry whose protein(s) existence is based on evidence at protein level
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1 22 3
GENE REF ISO

Function

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Overview 
Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. Also displays broad nucleoside diphosphate kinase activity.  
2
  • CuratedUniProtKB
GO molecular function 
Adenylate kinase activitydefinition[GO:0004017]  
  • IEAEC 2 GO
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Nucleoside diphosphate kinase activitydefinition[GO:0004550]  
1
  • IDAUniProtKB
GO biological process 
ADP biosynthetic processdefinition[GO:0006172]  
1
  • TASPINC
ATP metabolic processdefinition[GO:0046034] silver  
  • IEAInterPro 2 GO
dADP biosynthetic processdefinition[GO:0006173]  
1
  • TASPINC
Nucleoside diphosphate phosphorylationdefinition[GO:0006165]  
1
  • IDAUniProtKB
Nucleoside triphosphate biosynthetic processdefinition[GO:0009142]  
1
  • IDAUniProtKB
Pyrimidine ribonucleotide biosynthetic processdefinition[GO:0009220]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 2.7.4.3: ATP + AMP 2 ADP.  
2
  • CuratedUniProtKB
EC 2.7.4.6: ATP + nucleoside diphosphate ADP + nucleoside triphosphate.  
2
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+26289  
Purine metabolism  hsa00230+26289  
According to Reactome, this protein belongs to the following pathway:
Synthesis and interconversion of nucleotide di- and triphosphates  REACT_21330  
 
More information is available from:
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 26289
PRO: PR:Q9Y6K8