IKBKG - NF-kappa-B essential modulator - human protein (Function)
 
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IKBKG »  NF-kappa-B essential modulator  (NEMO)
 
Protein also known as:  Inhibitor of nuclear factor kappa-B kinase subunit gamma (IKKG).
Gene name:  IKBKG
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 228 3
GENE REF ISO

Function

 show evidences
Overview 
Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination.  
3
  • CuratedUniProtKB
GO molecular function 
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
40
  • IPIIntAct
  • IPIUniProtKB
  • IPIBHF-UCL
  • IPIHGNC
Protein domain specific bindingdefinition[GO:0019904]  
1
  • IPIUniProtKB
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • IDAUniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IDAUniProtKB
Signal transducer activitydefinition[GO:0004871]  
1
  • TASPINC
GO biological process 
Activation of NF-kappaB-inducing kinase activitydefinition[GO:0007250] silver  
  • IEAOrtholog Compara
Apoptotic processdefinition[GO:0006915]  
1
  • TASPINC
B cell homeostasisdefinition[GO:0001782] silver  
  • IEAOrtholog Compara
Cellular response to DNA damage stimulusdefinition[GO:0006974]  
1
  • IDAUniProtKB
I-kappaB kinase/NF-kappaB signalingdefinition[GO:0007249]  
1
  • TASUniProtKB
Immune responsedefinition[GO:0006955]  
1
  • TASPINC
Inflammatory responsedefinition[GO:0006954]  
1
  • TASUniProtKB
Innate immune responsedefinition[GO:0045087]  
1
  • TASUniProtKB
Positive regulation of NF-kappaB transcription factor activitydefinition[GO:0051092]  
2
  • TASUniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IDAUniProtKB
Response to virusdefinition[GO:0009615]  
1
  • TASUniProtKB
T cell receptor signaling pathwaydefinition[GO:0050852]  
2
  • TASUniProtKB
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
Acute myeloid leukemia  hsa05221+8517  
Adipocytokine signaling pathway  hsa04920+8517  
Apoptosis  hsa04210+8517  
B cell receptor signaling pathway  hsa04662+8517  
Chagas disease (American trypanosomiasis)  hsa05142+8517  
Chemokine signaling pathway  hsa04062+8517  
Chronic myeloid leukemia  hsa05220+8517  
Cytosolic DNA-sensing pathway  hsa04623+8517  
Epithelial cell signaling in Helicobacter pylori infection  hsa05120+8517  
Hepatitis C  hsa05160+8517  
Herpes simplex infection  hsa05168+8517  
HTLV-I infection  hsa05166+8517  
MAPK signaling pathway  hsa04010+8517  
NOD-like receptor signaling pathway  hsa04621+8517  
Osteoclast differentiation  hsa04380+8517  
Pancreatic cancer  hsa05212+8517  
Pathways in cancer  hsa05200+8517  
Primary immunodeficiency  hsa05340+8517  
Prostate cancer  hsa05215+8517  
RIG-I-like receptor signaling pathway  hsa04622+8517  
Shigellosis  hsa05131+8517  
Small cell lung cancer  hsa05222+8517  
T cell receptor signaling pathway  hsa04660+8517  
Toll-like receptor signaling pathway  hsa04620+8517  
Toxoplasmosis  hsa05145+8517  
According to Reactome, this protein belongs to the following pathways:
activated TAK1 mediates p38 MAPK activation  REACT_21399  
Activation of NF-kappaB in B cells  REACT_118656  
Downstream TCR signaling  REACT_12555  
FCERI mediated NF-kB activation  REACT_163994  
IKK complex recruitment mediated by RIP1  REACT_25374  
Interleukin-1 signaling  REACT_22442  
IRAK1 recruits IKK complex  REACT_24918  
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation  REACT_25354  
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1  REACT_21368  
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10  REACT_25039  
NOD1/2 Signaling Pathway  REACT_75776  
RIP-mediated NFkB activation via ZBP1  REACT_118563  
TAK1 activates NFkB by phosphorylation and activation of IKKs complex  REACT_21281  
TRAF6 mediated NF-kB activation  REACT_24969  
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q9Y6K9
Other
GeneWiki: IKBKG
GenomeRNAi: 8517
PRO: PR:Q9Y6K9